ArticleJournal of medical primatology2012
Innate immune responses to TLR2 and TLR4 agonists differ between baboons, chimpanzees and humans.
Article in Journal of medical primatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Discordant biological and toxicological species responses to TLR3 activation.The American journal of pathology · 2014Trial
- A review of gut failure as a cause and consequence of critical illness.Critical care (London, England) · 2025Review
- Primate innate immune responses to bacterial and viral pathogens reveals an evolutionary trade-off between strength and specificity.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- TLR4 Signaling by Heme and the Role of Heme-Binding Blood Proteins.Frontiers in immunology · 2020Review
- Loss of CMAH during Human Evolution Primed the Monocyte-Macrophage Lineage toward a More Inflammatory and Phagocytic State.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Review
- Immunological and technical considerations in application of alginate-based microencapsulation systems.Frontiers in bioengineering and biotechnology · 2014Review
- A comparative review of toll-like receptor 4 expression and functionality in different animal species.Frontiers in immunology · 2014Review
- Thyroid autoantibodies are rare in nonhuman great apes and hypothyroidism cannot be attributed to thyroid autoimmunity.Endocrinology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundAfrican catarrhine primates differ in bacterial disease susceptibility.
methodsHuman, chimpanzee, and baboon blood were stimulated with TLR-detected bacterial agonists and cytokine/chemokine induction assessed by real-time PCR.
resultsHumans and chimpanzees shared similar cytokine/chemokine responses, while baboon cytokine/chemokine induction differed. Generally, responses were agonist independent.
conclusionsThese primates tend to generate species rather than agonist-specific responses to bacterial agonists.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.