ArticleCardiovascular diabetology2012
Cystatin C and asymptomatic coronary artery disease in patients with metabolic syndrome and normal glomerular filtration rate.
Article in Cardiovascular diabetology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Cystatin C Is a Predictor for Long-Term, All-Cause, and Cardiovascular Mortality in US Adults With Metabolic Syndrome.The Journal of clinical endocrinology and metabolism · 2024Article
- The role of inflammation, oxidation and Cystatin-C in the pathophysiology of polycystic ovary syndrome.Turkish journal of obstetrics and gynecology · 2022Article
- Urinary Cystatin C Has Prognostic Value in Peripheral Artery Disease.Biomolecules · 2022Article
- Renal and Inflammation Markers-Renalase, Cystatin C, and NGAL Levels in Asymptomatic and Symptomatic SARS-CoV-2 Infection in a One-Month Follow-Up Study.Diagnostics (Basel, Switzerland) · 2022Article
- Serum Cystatin C Predicts Stroke Clinical Outcomes at 1 Year Independent of Renal Function.Frontiers in neurology · 2021Article
- Clinical utility of serum cystatin C for prediction of multi-vessel disease by coronary angiography in type 2 diabetes mellitus patients with normal renal function.BMC cardiovascular disorders · 2020Article
- Association of Cystatin C with Metabolic Syndrome and Its Prognostic Performance in Non-ST-Segment Elevation Acute Coronary Syndrome with Preserved Renal Function.BioMed research international · 2019Article
- Serum cystatin C and neutrophil gelatinase-associated lipocalin in predicting the severity of coronary artery disease in diabetic patients.Anatolian journal of cardiology · 2016Article
- Relationship between High Serum Cystatin C Levels and the Risk of Gestational Diabetes Mellitus.PloS one · 2016Article
- Association of genetic variants with coronary artery disease and ischemic stroke in a longitudinal population-based genetic epidemiological study.Biomedical reports · 2015Article
- Assessment of Serum Cystatin C Levels in Newly Diagnosed Acute Myocardial Infarction at the Onset and at the Time of Hospital Discharge.Cardiology research · 2015Article
- Association between left ventricular end-diastolic pressure and coronary artery disease as well as its extent and severity.International journal of clinical and experimental medicine · 2015Article
- The potential of Cystatin C and small dense LDL as biomarkers of coronary artery disease risk in a young Indian population.Molecular and cellular biochemistry · 2014Article
- Extracellular vesicle markers in relation to obesity and metabolic complications in patients with manifest cardiovascular disease.Cardiovascular diabetology · 2014Article
- Article
- Association of genetic variants of the α-kinase 1 gene with myocardial infarction in community-dwelling individuals.Biomedical reports · 2014Article
- Long-term prognostic impact of cystatin C on acute coronary syndrome octogenarians with diabetes mellitus.Cardiovascular diabetology · 2013Article
- Immunomodulatory and antibacterial effects of cystatin 9 against Francisella tularensis.Molecular medicine (Cambridge, Mass.) · 2013Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAll of the components of metabolic syndrome (MetS) have been regarded as risk factors for coronary artery disease (CAD). Early detection of CAD in asymptomatic patients with MetS remains a challenge. Cystatin C,which has been proposed as a novel marker of renal dysfunction,is correlated with mortality in CAD, The purpose of the study was to evaluate whether cystatin C is a potential marker of asymptomatic CAD in MetS patients with normal kidney function.
methodsA total of 211asymptomatic MetS patients without prior history of CAD patients were included in a cross-sectional study. Patients were divided into MetS with asymptomatic CAD (n=136) and MetS without CAD (n=75) groups according to coronary angiograph results. Serum cystatin C levels were measured using particle enhanced immunonephelometric assays. We first assessed whether there is an independent association of cystatin C with the presence and severity of asymptomatic CAD. Then, we investigated the association between cystatin C and other biochemical risk factors for atherosclerosis.
resultsSerum cystatin C levels in patients with asymptomatic CAD were significantly higher than those without CAD (P=0.004). A multiple logistic regression analysis demonstrated cystatin C was independently associated with the presence of asymptomatic CAD (OR=1.326, 95%CI: 1.086-1.619). On receiver operating characteristics (ROC) analysis, the area under the curve (AUC) was 0.622 (95% CI: 0543-0.701, P=0.003), and cystatin C showed a moderate predictive value. Furthermore, cystatin C was independently correlated with Gensini score (standardized β=0.183, P=0.007), and serum cystatin C levels increased with the increasing of number of disease vessels (P=0.005). In a multiple stepwise regression analysis, uric acid (UA)(P<0.001), body mass index (BMI)(P=0.002), triglyceride(TG)(P=0.03), estimated glomerular filtration rate (eGFR)(P<0.001), and fibrinogen(P=0.001) were independently associated with cystatin C.
conclusionsSerum cystatin C in our study was significantly associated with the presence and severity of asymptomatic CAD in MetS patients with normal kidney function, suggesting that cystatin C is probably more than a marker of glomerular filtration rate.
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