ArticleComputer methods in biomechanics and biomedical engineering2014
Computational analysis of lung deformation after murine pneumonectomy. [corrected].
Article in Computer methods in biomechanics and biomedical engineering, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Single-Cell Transcriptional Profiling of Cells Derived From Regenerating Alveolar Ducts.Frontiers in medicine · 2020Article
- Deformation-induced transitional myofibroblasts contribute to compensatory lung growth.American journal of physiology. Lung cellular and molecular physiology · 2017Article
- Evidence for pleural epithelial-mesenchymal transition in murine compensatory lung growth.PloS one · 2017Article
- Elastin Cables Define the Axial Connective Tissue System in the Murine Lung.Anatomical record (Hoboken, N.J. : 2007) · 2015Article
- Remodeling of alveolar septa after murine pneumonectomy.American journal of physiology. Lung cellular and molecular physiology · 2015Article
- Sprouting and intussusceptive angiogenesis in postpneumonectomy lung growth: mechanisms of alveolar neovascularization.Angiogenesis · 2014Article
- Mapping cyclic stretch in the postpneumonectomy murine lung.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
Corrections and comments
- Erratum issuedCorrigendum.2016
Authors and funding
6 authors.
Funding
Abstract
In many mammalian species, the removal of one lung (pneumonectomy) is associated with the compensatory growth of the remaining lung. To investigate the hypothesis that parenchymal deformation may trigger lung regeneration, we used microCT scanning to create 3D finite element geometric models of the murine lung pre- and post-pneumonectomy (24 h). The structural correspondence between models was established using anatomic landmarks and an iterative computational algorithm. When compared with the pre-pneumonectomy lung, the post-pneumonectomy models demonstrated significant translation and rotation of the cardiac lobe into the post-pneumonectomy pleural space. 2D maps of lung deformation demonstrated significant heterogeneity; the areas of greatest deformation were present in the subpleural regions of the lobe. Consistent with the previously identified growth patterns, subpleural regions of enhanced deformation are compatible with a mechanical signal - likely involving parenchymal stretch - triggering lung growth.
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Registered trials
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