ArticleOphthalmic epidemiology2012
Glaucoma, Alzheimer disease and other dementia: a longitudinal analysis.
Article in Ophthalmic epidemiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 5 syntheses or guidelines pooled it, 91 citations in OpenAlex.
- Population attributable fractions of a wide range of peripheral diseases for the burden of dementia.Nature human behaviour · 2026Pooled it
- Risk of glaucoma to subsequent dementia or cognitive impairment: a systematic review and meta-analysis.Aging clinical and experimental research · 2024Pooled it
- Relative Risks for Dementia among Individuals with Glaucoma: A Meta-Analysis of Observational Cohort Studies.Korean journal of ophthalmology : KJO · 2023Pooled it
- Frequency of coexistent eye diseases and cognitive impairment or dementia: a systematic review and meta-analysis.Eye (London, England) · 2023Pooled it
- Glaucoma Is Not Associated With Alzheimer's Disease or Dementia: A Meta-Analysis of Cohort Studies.Frontiers in medicine · 2021Pooled it
- The Association between Glaucoma and Dementia in a National Cohort of All of Us Participants.Ophthalmology · 2026Article
- A Narrative Review of the Association Between Cataracts and Dementia.Eye and brain · 2025Review
- Topological Organization of the Brain Network in Patients with Primary Angle-closure Glaucoma Through Graph Theory Analysis.Brain topography · 2024Article
- MRI and Clinical Biomarkers Overlap between Glaucoma and Alzheimer's Disease.International journal of molecular sciences · 2023Review
- Could Mid- to Late-Onset Glaucoma Be Associated with an Increased Risk of Incident Dementia? A Nationwide Retrospective Cohort Study.Journal of personalized medicine · 2023Article
- Normal-tension glaucoma is associated with cognitive impairment.The British journal of ophthalmology · 2022Article
- TheOphthalmology science · 2022Article
- MRI findings suggestive of Alzheimer's disease in patients with primary open angle glaucoma - a single sequence analysis using rapid 3D T1 spoiled gradient echo.The British journal of radiology · 2022Article
- A Component or Multiple Components of Bleeding Gums May Ameliorate Both Glaucoma and Alzheimer's Disease.Cureus · 2022Article
- Ophthalmic conditions associated with dementia risk: The Cardiovascular Health Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021Article
- Individuals with and without normal tension glaucoma exhibit comparable performance on tests of cognitive function.International journal of ophthalmology · 2021Article
- Association between open-angle glaucoma and Alzheimer's disease in Sweden: a long-term population-based follow-up study.Upsala journal of medical sciences · 2021Article
- Retinal biomarkers for Alzheimer's disease and vascular cognitive impairment and dementia (VCID): implication for early diagnosis and prognosis.GeroScience · 2020Review
- Neurodegeneration in Alzheimer's disease and glaucoma: overlaps and missing links.Eye (London, England) · 2020Review
- Longitudinal analysis of dementia diagnosis and specialty care among racially diverse Medicare beneficiaries.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo evaluate the risk of developing Alzheimer disease (AD) or other dementia in patients diagnosed with open-angle glaucoma (OAG) in a nationally representative longitudinal sample of elderly persons.
methodsThis retrospective cohort study (January 1, 1994-December 31, 2007) used Medicare 5% claims data. We identified beneficiaries aged 68+ years who had at least two claims with diagnoses of OAG and no Alzheimer or other dementia in 1994, using a 3-year look-back period between 1991 and 1993 (n = 63,235) and beneficiaries matched on age, sex, race, and Charlson index without a diagnosis of OAG throughout the observational period (n = 63,235), using propensity score matching. Using a Cox Proportional Hazards model, we analyzed time to AD diagnosis and time to AD or other dementia diagnosis.
resultsElderly individuals diagnosed with OAG did not have an increased rate of AD and other dementia diagnosis compared to those without OAG during a 14-year follow-up period, even after controlling for relevant covariates present at baseline.
conclusionsIndividuals aged 68+ years diagnosed with OAG have a decreased rate of AD or other dementia diagnosis compared to control patients without an OAG diagnosis. Although OAG and AD are both age-related neurodegenerative diseases, our findings do not support a positive association.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.