ArticleBMC evolutionary biology2012
Can phylogeny predict chemical diversity and potential medicinal activity of plants? A case study of Amaryllidaceae.
Article in BMC evolutionary biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39 citing papers in PubMed.
- Plasmonic artificial inspector for herbal medicines via surface-enhanced Raman spectroscopy and deep learning.Scientific reports · 2026Article
- Acteoside exerts neuroprotective effects by preventing α-synuclein aggregation and oxidative stress in models of Parkinson's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- Beyond phylogeny: phytochemical diversity as a unique metric for biodiversity in the Gentianales.The New phytologist · 2025Article
- Evolutionary Tree in Chemical Space of Natural Products.bioRxiv : the preprint server for biology · 2025Article
- The origin and diversification of Amaryllidaceae: A phylogenetic and biogeographic analysis.American journal of botany · 2025Article
- Endosperm culture-based allotriploid hybrid production from an interspecific cross of Haemanthus spp.: new insights into polyploidization and hybridization.BMC plant biology · 2025Article
- Navigating Amaryllidaceae alkaloids: bridging gaps and charting biosynthetic territories.Journal of experimental botany · 2025Review
- Bioprospecting of Artemisia genus: from artemisinin to other potentially bioactive compounds.Scientific reports · 2024Article
- Machine learning enhances prediction of plants as potential sources of antimalarials.Frontiers in plant science · 2023Article
- Comment on Pyrrolizidine Alkaloids and Terpenes fromMolecules (Basel, Switzerland) · 2022Article
- Effect of Different Physical Factors on efficacy ofBiochemistry and biophysics reports · 2022Article
- Mass Spectrometry Metabolomics and Feature-Based Molecular Networking Reveals Population-Specific Chemistry in Some Species of theFrontiers in nutrition · 2022Article
- The Role of Botanical Families in Medicinal Ethnobotany: A Phylogenetic Perspective.Plants (Basel, Switzerland) · 2021Article
- Comparative plastomics of Amaryllidaceae: inverted repeat expansion and the degradation of thePeerJ · 2021Article
- The complete plastome of the South African species,Mitochondrial DNA. Part B, Resources · 2021Article
- Side-stream products of malting: a neglected source of phytochemicals.NPJ science of food · 2020Article
- Plant phylogeny drives arboreal caterpillar assemblages across the Holarctic.Ecology and evolution · 2020Article
- COVID-19: Phylogenetic approaches may help in finding resources for natural cure.Phytotherapy research : PTR · 2020Article
- Evaluation of plant sources for antiinfective lead compound discovery by correlating phylogenetic, spatial, and bioactivity data.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The Phylum Bryozoa: From Biology to Biomedical Potential.Marine drugs · 2020Review
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12 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundDuring evolution, plants and other organisms have developed a diversity of chemical defences, leading to the evolution of various groups of specialized metabolites selected for their endogenous biological function. A correlation between phylogeny and biosynthetic pathways could offer a predictive approach enabling more efficient selection of plants for the development of traditional medicine and lead discovery. However, this relationship has rarely been rigorously tested and the potential predictive power is consequently unknown.
resultsWe produced a phylogenetic hypothesis for the medicinally important plant subfamily Amaryllidoideae (Amaryllidaceae) based on parsimony and Bayesian analysis of nuclear, plastid, and mitochondrial DNA sequences of over 100 species. We tested if alkaloid diversity and activity in bioassays related to the central nervous system are significantly correlated with phylogeny and found evidence for a significant phylogenetic signal in these traits, although the effect is not strong.
conclusionsSeveral genera are non-monophyletic emphasizing the importance of using phylogeny for interpretation of character distribution. Alkaloid diversity and in vitro inhibition of acetylcholinesterase (AChE) and binding to the serotonin reuptake transporter (SERT) are significantly correlated with phylogeny. This has implications for the use of phylogenies to interpret chemical evolution and biosynthetic pathways, to select candidate taxa for lead discovery, and to make recommendations for policies regarding traditional use and conservation priorities.
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