ReviewOpen biology2012
On the inscrutable role of Inscuteable: structural basis and functional implications for the competitive binding of NuMA and Inscuteable to LGN.
Review in Open biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Elevated temperature fatally disrupts nuclear divisions in the early Drosophila embryo.Nature communications · 2026Article
- Article
- Kinesin-binding protein remodels the kinesin motor to prevent microtubule binding.Science advances · 2021Article
- Review
- Modeling the cornea in 3-dimensions: Current and future perspectives.Experimental eye research · 2020Review
- Zeb1 is important for proper cleavage plane orientation of dividing progenitors and neuronal migration in the mouse neocortex.Cell death and differentiation · 2019Article
- G-protein-signaling modulator 2 expression and role in a CD133OncoTargets and therapy · 2019Article
- Insc:LGN tetramers promote asymmetric divisions of mammary stem cells.Nature communications · 2018Article
- The asymmetric cell division machinery in the spiral-cleaving egg and embryo of the marine annelid Platynereis dumerilii.BMC developmental biology · 2017Article
- VE-Cadherin Phosphorylation Regulates Endothelial Fluid Shear Stress Responses through the Polarity Protein LGN.Current biology : CB · 2017Article
- Extracellular Regulation of the Mitotic Spindle and Fate Determinants Driving Asymmetric Cell Division.Results and problems in cell differentiation · 2017Review
- Crystallization and X-ray diffraction of LGN in complex with the actin-binding protein afadin.Acta crystallographica. Section F, Structural biology communications · 2016Article
- The GPSM2/LGN GoLoco motifs are essential for hearing.Mammalian genome : official journal of the International Mammalian Genome Society · 2016Article
- Concomitant binding of Afadin to LGN and F-actin directs planar spindle orientation.Nature structural & molecular biology · 2016Article
- Mammary Stem Cell Self-Renewal Is Regulated by Slit2/Robo1 Signaling through SNAI1 and mINSC.Cell reports · 2015Article
- The kinetochore protein, CENPF, is mutated in human ciliopathy and microcephaly phenotypes.Journal of medical genetics · 2015Article
- Aurora kinases phosphorylate Lgl to induce mitotic spindle orientation in Drosophila epithelia.Current biology : CB · 2015Article
- A unique set of centrosome proteins requires pericentrin for spindle-pole localization and spindle orientation.Current biology : CB · 2014Article
- Stem cell decisions: a twist of fate or a niche market?Seminars in cell & developmental biology · 2014Review
- Analysis and modeling of mitotic spindle orientations in three dimensions.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alignment of the mitotic spindle to the cellular polarity axis is a prerequisite for asymmetric cell divisions. The protein network coordinating the spindle position with cortical polarity includes the molecular machinery pulling on astral microtubules, which is assembled on conserved NuMA:LGN:Gαi complexes, the polarity proteins Par3:Par6:aPKC and an adaptor molecule known as Inscuteable (Insc). To date, all these components were assumed to enter a macromolecular complex localized at polarity sites in mitosis. However, recent structural studies revealed the Insc and NuMA are mutually exclusive interactors of LGN, implying that the molecular mechanism of spindle coupling to polarity is more sophisticated than has been believed to date.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.