ArticleScientific reports2012
The cell cycle switch computes approximate majority.
Article in Scientific reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Bio-inspired decision making in robot swarms under biases.Nature communications · 2026Article
- Abstraction-based segmental simulation of reaction networks using adaptive memoization.BMC bioinformatics · 2024Article
- There's Plenty of Room Right Here: Biological Systems as Evolved, Overloaded, Multi-Scale Machines.Biomimetics (Basel, Switzerland) · 2023Article
- Distributed algorithms from arboreal ants for the shortest path problem.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Operant conditioning of stochastic chemical reaction networks.PLoS computational biology · 2022Article
- Robust finite automata in stochastic chemical reaction networks.Royal Society open science · 2021Article
- The role of memory in non-genetic inheritance and its impact on cancer treatment resistance.PLoS computational biology · 2021Article
- Communication cost of consensus for nodes with limited memory.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Two Interlinked Bistable Switches Govern Mitotic Control in Mammalian Cells.Current biology : CB · 2018Article
- Scaling up molecular pattern recognition with DNA-based winner-take-all neural networks.Nature · 2018Article
- Single molecules can operate as primitive biological sensors, switches and oscillators.BMC systems biology · 2018Article
- Computing with biological switches and clocks.Natural computing · 2018Article
- Chemical reaction network designs for asynchronous logic circuits.Natural computing · 2018Article
- Programming discrete distributions with chemical reaction networks.Natural computing · 2018Article
- Interlinked bistable mechanisms generate robust mitotic transitions.Cell cycle (Georgetown, Tex.) · 2017Review
- Modelling the spread of innovation in wild birds.Journal of the Royal Society, Interface · 2017Article
- Efficient Switches in Biology and Computer Science.PLoS computational biology · 2017Article
- Stochasticity in the Genotype-Phenotype Map: Implications for the Robustness and Persistence of Bet-Hedging.Genetics · 2016Article
- Modular verification of chemical reaction network encodings via serializability analysis.Theoretical computer science · 2016Article
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Authors and funding
2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Both computational and biological systems have to make decisions about switching from one state to another. The 'Approximate Majority' computational algorithm provides the asymptotically fastest way to reach a common decision by all members of a population between two possible outcomes, where the decision approximately matches the initial relative majority. The network that regulates the mitotic entry of the cell-cycle in eukaryotes also makes a decision before it induces early mitotic processes. Here we show that the switch from inactive to active forms of the mitosis promoting Cyclin Dependent Kinases is driven by a system that is related to both the structure and the dynamics of the Approximate Majority computation. We investigate the behavior of these two switches by deterministic, stochastic and probabilistic methods and show that the steady states and temporal dynamics of the two systems are similar and they are exchangeable as components of oscillatory networks.
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