ArticleExperimental and therapeutic medicine2011
IGF1 mRNA isoform expression in the cervix of HPV-positive women with pre-cancerous and cancer lesions.
Article in Experimental and therapeutic medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Insulin-like Growth Factor 1 (IGF1) and Its Isoforms: Insights into the Mechanisms of Endometrial Cancer.Cancers · 2025Review
- The IGF-1 Signaling Pathway in Viral Infections.Viruses · 2021Review
- Immunohistochemical expression of insulin-like growth factor-1Ec in primary endometrial carcinoma: Association with PTEN, p53 and survivin expression.Oncology letters · 2020Article
- Role of Alternatively Spliced Messenger RNA (mRNA) Isoforms of the Insulin-Like Growth Factor 1 (IGF1) in Selected Human Tumors.International journal of molecular sciences · 2020Review
- IPF pathogenesis is dependent upon TGFβ induction of IGF-1.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- IGF-IEc expression is increased in secondary compared to primary foci in neuroendocrine neoplasms.Oncotarget · 2017Article
- Human IGF1 pro-forms induce breast cancer cell proliferation via the IGF1 receptor.Cellular oncology (Dordrecht, Netherlands) · 2016Article
- Insulin-like growth factor-1 mRNA isoforms and insulin-like growth factor-1 receptor mRNA expression in chronic hepatitis C.World journal of gastroenterology · 2015Article
- IGF axis and other factors in HPV-related and HPV-unrelated carcinogenesis (review).Oncology reports · 2014Review
- IGF expression in HPV-related and HPV-unrelated human cancer cells.Oncology reports · 2014Article
- The complexity of the IGF1 gene splicing, posttranslational modification and bioactivity.Molecular medicine (Cambridge, Mass.) · 2014Review
- Evidence for the Possible Biological Significance of the igf-1 Gene Alternative Splicing in Prostate Cancer.Frontiers in endocrinology · 2013Article
- Expression of various insulin-like growth factor-1 mRNA isoforms in colorectal cancer.Contemporary oncology (Poznan, Poland) · 2012Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human papillomavirus (HPV) plays a crucial role in cervical cancer etiology. However, not all HPV-infected women develop cancer, indicating that additional cellular factors facilitate carcinogenesis. The aim of this study was to analyze the expression profile of insulin-like growth factor 1 (IGF1) isoforms in the context of FOX2, SP1 and IGF1 receptor (IGF1R) expression during HPV-dependent cervical carcinogenesis. One hundred and nine epithelial tissue samples from women with pre-cancerous and cancer lesions of the cervix were analyzed. HPV DNA was identified by PCR, and real-time PCR was used to quantify the expression levels of the analyzed genes. All IGF1 mRNA splicing isoforms were up-regulated in pre-cancerous cells, and a shift in the balance towards mitogenic IGF1Eb was observed in the cancer samples. IGF1 expression was controlled mainly by the P1 promoter, and an increase in P2 usage was observed in the cancer. Correlations between IGF1 mRNA splicing isoforms and the FOX2 splicing factor, as well as P1/P2 activity and SP1 transcription factor expression levels were detected. No correlation was observed between the expression of IGF1 and its receptor IGF1R. Our results suggest that IGF1, in particular its splicing profile, may be an additional prognostic factor in cervical carcinogenesis.
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Registered trials
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