ArticleThe Malaysian journal of medical sciences : MJMS2012
Effect of calabash chalk on the histomorphology of the gastro-oesophageal tract of growing wistar rats.
Article in The Malaysian journal of medical sciences : MJMS, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Evaluation of prenatal calabash chalk geophagy on the developing brain of Wistar rats.IBRO neuroscience reports · 2024Article
- Chemical analysis of calabash chalk and its effect on locomotor activities and behavior inHeliyon · 2023Article
- Frequency, types, and factors associated with complementary and alternative medicine use among patients on maintenance haemodialysis.BMC complementary medicine and therapies · 2022Article
- High umbilical cord blood lead levels and "calabar chalk" consumption amongst pregnant women in two hospitals in Cameroon.The Pan African medical journal · 2019Article
- Plain Radiograph of Abdomen Mimicking Contrast Study.The Indian journal of surgery · 2018Article
- Maternal Geophagy of Calabash Chalk on Foetal Cerebral Cortex Histomorphology.The Malaysian journal of medical sciences : MJMSArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCalabash chalk is a naturally occurring mineral consumed by members of some Nigerian communities for pleasure and by pregnant women as a remedy for morning sickness. The consumption of this geophagic material motivated our interest on the effect of the chalk on the histomorphology of the gastro-oesophageal tract.
methodsTwenty-eight young Wistar rats, 4 weeks old, were divided into 4 groups of equal size. Group 1 animals served as controls and received 1 mL of distilled water. Groups 2, 3, and 4 received orally 1 mL of a Calabash chalk suspension containing 40 mg/mL for 14, 21, and 28 days, respectively. Upon completion of the treatments, the animals in groups 2, 3, and 4 were sacrificed on days 15, 22, and 29, respectively, and the control group animals were sacrificed on day 29. All animals were euthanised using chloroform anaesthesia. The oesophagus and the stomach of each animal were dissected out and routinely processed for histological studies.
resultsThere was oedema with haemorrhages in the mucosa of the stomach, and acanthosis, hyperkeratosis, and koilocytic changes were observed in the mucosa of the oesophagus of the groups treated with 40 mg/mL of Calabash chalk suspension.
conclusionCalabash chalk caused histological changes to the stomach and the oesophagus that may lead to other pathophysiological conditions.
Indexed as
Identifiers
22977372PMC3436492W2407732623What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.