Trial reportJournal of neurointerventional surgery2013
Impact of operator and site experience on outcomes after angioplasty and stenting in the SAMMPRIS trial.
Trial report in Journal of neurointerventional surgery, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00576693 (Stenting vs. Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis), which is not on this map. Cited by 34 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Stenting vs. Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis
Who cites it
34 citing papers in PubMed, 4 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Intracranial stenting versus aggressive medical therapy for symptomatic intracranial stenosis: A meta-analysis of multicenter randomized controlled trials and an expert assessment of the current data.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026Pooled it
- Robotic versus manual diagnostic and stenting procedures: a systematic review and meta-analysis.Neurosurgical review · 2024Pooled it
- Percutaneous transluminal angioplasty and stenting vs aggressive medical management on stroke or intracranial atherosclerotic stenosis: a systematic review and meta-analysis.Scientific reports · 2023Pooled it
- Safety and efficacy of stenting for symptomatic intracranial artery stenosis: a systematic reveiw and meta-analysis.Frontiers in pharmacology · 2023Pooled it
- Effect of Stenting Plus Medical Therapy vs Medical Therapy Alone on Risk of Stroke and Death in Patients With Symptomatic Intracranial Stenosis: The CASSISS Randomized Clinical Trial.JAMA · 2022 · on this mapTrial
- Comparison of Drug-Eluting Stent With Bare-Metal Stent in Patients With Symptomatic High-grade Intracranial Atherosclerotic Stenosis: A Randomized Clinical Trial.JAMA neurology · 2022Trial
- Peri-procedural stroke or death in stenting of symptomatic severe intracranial stenosis.Journal of neurointerventional surgery · 2020Trial
- Trial
- Angioplasty and stenting for patients with symptomatic intracranial atherosclerosis: study protocol of a randomised controlled trial.BMJ open · 2016Trial
- Trial
- Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): the final results of a randomised trial.Lancet (London, England) · 2014 · on this mapTrial
- Mechanisms of stroke after intracranial angioplasty and stenting in the SAMMPRIS trial.Neurosurgery · 2013Trial
- Article
- Safety of endovascular therapy for symptomatic intracranial artery stenosis: a national prospective registry.Stroke and vascular neurology · 2022Article
- Comprehensive Risk Analysis of the Wingspan Stent in Relation to Target Vessels.Journal of neuroendovascular therapy · 2022Article
- Prevalence, prognosis, and treatment of atherosclerotic intracranial stenosis in Caucasians.International journal of stroke : official journal of the International Stroke Society · 2021Article
- Stenting for intracranial stenosis: potential future for the prevention of disabling or fatal stroke.Stroke and vascular neurology · 2018Review
- Endovascular Treatment of Intracranial Atherosclerotic Stenosis: Current Debates and Future Prospects.Frontiers in neurology · 2018Article
- Angioplasty, Stenting and Other Potential Treatments of Atherosclerotic Stenosis of the Intracranial Arteries: Past, Present and Future.Journal of stroke · 2017Review
- Stroke Caused by Atherosclerosis of the Major Intracranial Arteries.Circulation research · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 9 institutions in 1 country.
Funding
Abstract
background and purposeTo investigate the relationship between physician and site experience and the risk of 30 day hemorrhagic and ischemic strokes in the stenting arm of the Stenting and Aggressive Medical Management for the Prevention of Recurrent Ischemic Stroke (SAMMPRIS) trial.
methodsStudy records and an investigator survey were examined for physician and site related factors, including: number of Wingspan and aneurysm stents submitted for credentialing, number of study procedures performed in SAMMPRIS, years in practice after training, primary specialty, and site enrollment. Bivariate and multivariate analyses were performed to determine if these factors were associated with the 30 day rate of cerebrovascular events after angioplasty and stenting.
results213 patients underwent angioplasty alone (n=5) or angioplasty and stenting (n=208) with study devices by 63 interventionists at 48 sites. For credentialing, the median number of Wingspan and similar aneurysm stent cases submitted by study interventionists were 10 and 6, respectively. Interventionists with higher numbers (>10) of Wingspan cases submitted for credentialing tended to have higher rates of 30 day events (19.0% vs 9.9%) than those with <10 cases. High enrolling sites in the trial tended to have lower rates of hemorrhagic stroke (9.8% at sites enrolling <12 patients vs 2.7% at sites enrolling >12 patients).
conclusionsInterventionists credentialed with less Wingspan experience were not responsible for the high rate of periprocedural stroke in SAMMPRIS. Hemorrhagic stroke may be related to low enrollment in the trial but not previous Wingspan experience.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.