ArticleEuropean heart journal2013
Influence of common genetic variation on blood lipid levels, cardiovascular risk, and coronary events in two British prospective cohort studies.
Article in European heart journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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20 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Association of cholesteryl ester transfer protein (CETP) gene polymorphism, high density lipoprotein cholesterol and risk of coronary artery disease: a meta-analysis using a Mendelian randomization approach.BMC medical genetics · 2014Pooled it
- Revealing genetic foundations underlying cardiometabolic traits: integrating twin and GWAS data in Asian populations.International journal of obesity (2005) · 2026Article
- Influence of Common Gene Variants on Lipid Levels and Risk of Coronary Heart Disease in Afro-Caribbeans.International journal of molecular sciences · 2024Article
- Cholesterol associated genetic risk score and acute coronary syndrome in Czech males.Molecular biology reports · 2024Article
- Influence of multiple apolipoprotein A-I and B genetic variations on insulin resistance and metabolic syndrome in obstructive sleep apnea.Nutrition & metabolism · 2020Article
- Article
- Total cholesterol variability and risk of atrial fibrillation: A nationwide population-based cohort study.PloS one · 2019Observational
- Association of Multiple Genetic Variants with the Extension and Severity of Coronary Artery Disease.Arquivos brasileiros de cardiologia · 2018Article
- Excessive fuel availability amplifies the FTO-mediated obesity risk: results from the TUEF and Whitehall II studies.Scientific reports · 2017Article
- Novel genetic loci associated with long-term deterioration in blood lipid concentrations and coronary artery disease in European adults.International journal of epidemiology · 2017Article
- PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study.The lancet. Diabetes & endocrinology · 2017Article
- Associations of genetic variants for adult lipid levels with lipid levels in children. The Generation R Study.Journal of lipid research · 2016Article
- Risk prediction by genetic risk scores for coronary heart disease is independent of self-reported family history.European heart journal · 2016Observational
- Analysis of a cardiovascular disease genetic risk score in the Diabetes Heart Study.Acta diabetologica · 2015Article
- Associations of lipid levels susceptibility loci with coronary artery disease in Chinese population.Lipids in health and disease · 2015Article
- Biomarker tests for risk assessment in coronary artery disease: will they change clinical practice?Molecular diagnosis & therapy · 2014Review
- Sex-specific association of the peptidase D gene rs731839 polymorphism and serum lipid levels in the Mulao and Han populations.International journal of clinical and experimental pathology · 2014Article
- Cardiovascular disease risk prediction in women: is there a role for novel biomarkers?Clinical chemistry · 2014Review
- Impact of HDL genetic risk scores on coronary artery calcified plaque and mortality in individuals with type 2 diabetes from the Diabetes Heart Study.Cardiovascular diabetology · 2013Article
- Gly1057Asp polymorphism of insulin receptor substrate-2 is associated with coronary artery disease in the Taiwanese population.Journal of biomedical science · 2012Article
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Authors and funding
20 authors at 5 institutions in 2 countries.
Funding
Abstract
aimsThe aim of this study was to quantify the collective effect of common lipid-associated single nucleotide polymorphisms (SNPs) on blood lipid levels, cardiovascular risk, use of lipid-lowering medication, and risk of coronary heart disease (CHD) events. METHODS AND
resultsAnalysis was performed in two prospective cohorts: Whitehall II (WHII; N = 5059) and the British Women's Heart and Health Study (BWHHS; N = 3414). For each participant, scores were calculated based on the cumulative effect of multiple genetic variants influencing total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG). Compared with the bottom quintile, individuals in the top quintile of the LDL-C genetic score distribution had higher LDL-C {mean difference of 0.85 [95% confidence interval, (CI) = 0.76-0.94] and 0.63 [95% CI = 0.50-0.76] mmol/l in WHII and BWHHS, respectively}. They also tended to have greater odds of having 'high-risk' status (Framingham 10-year cardiovascular disease risk >20%) [WHII: odds ratio (OR) = 1.36 (0.93-1.98), BWHHS: OR = 1.49 (1.14-1.94)]; receiving lipid-lowering treatment [WHII: OR = 2.38 (1.57-3.59), BWHHS: OR = 2.24 (1.52-3.29)]; and CHD events [WHII: OR = 1.43 (1.02-2.00), BWHHS: OR = 1.31 (0.99-1.72)]. Similar associations were observed for the TC score in both studies. The TG score was associated with high-risk status and medication use in both studies. Neither HDL nor TG scores were associated with the risk of coronary events. The genetic scores did not improve discrimination over the Framingham risk score.
conclusionAt the population level, common SNPs associated with LDL-C and TC contribute to blood lipid variation, cardiovascular risk, use of lipid-lowering medications and coronary events. However, their effects are too small to discriminate future lipid-lowering medication requirements or coronary events.
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