ArticleClinical journal of the American Society of Nephrology : CJASN2012
Association of postoperative proteinuria with AKI after cardiac surgery among patients at high risk.
Article in Clinical journal of the American Society of Nephrology : CJASN, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Predictive and prognostic performance of urinary albumin-to-creatinine ratio for acute kidney injury: a systematic review and meta-analysis.Scientific reports · 2026Pooled it
- Urinary Biomarkers and Kidney Injury in VA NEPHRON-D: Phenotyping Acute Kidney Injury in Clinical Trials.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2024Pooled it
- Urine Biomarkers and Perioperative Acute Kidney Injury: The Impact of Preoperative Estimated GFR.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2015Trial
- Albuminuria, Forgotten No More: Underlining the Emerging Role in CardioRenal Crosstalk.Journal of clinical medicine · 2024Review
- Nephrology intervention to avoid acute kidney injury in patients awaiting cardiac surgery: randomized clinical trial.Frontiers in nephrology · 2024Article
- Acute Kidney Injury after Cardiac Surgery: Prediction, Prevention, and Management.Anesthesiology · 2023Review
- Renal Biomarkers in Cardiovascular Patients with Acute Kidney Injury: A Case Report and Literature Review.Diagnostics (Basel, Switzerland) · 2023Review
- Preoperative dipstick albuminuria is associated with acute kidney injury in high-risk patients following non-cardiac surgery: a single-center prospective cohort study.Journal of anesthesia · 2022Article
- Predictive value of preprocedural albuminuria for contrast-induced nephropathy non-recovery in patients undergoing percutaneous coronary intervention.International urology and nephrology · 2021Observational
- Incidence and Transition of Acute Kidney Injury, Acute Kidney Disease to Chronic Kidney Disease after Acute Type A Aortic Dissection Surgery.Journal of clinical medicine · 2021Article
- Silicone Oil Decreases Biofilm Formation in a Capacitance-Based Automatic Urine Measurement System.Sensors (Basel, Switzerland) · 2021Article
- AKI in Hospitalized Patients with COVID-19.Journal of the American Society of Nephrology : JASN · 2021Observational
- Proteinuria versus albuminuria in 24-hour urine collection: prevalence and clinical outcome in non-hypoxemic adult patients with congenital heart disease.American journal of cardiovascular disease · 2021Article
- The Many Faces of Matrix Metalloproteinase-7 in Kidney Diseases.Biomolecules · 2020Review
- Are Urinary Biomarkers Better Than Acute Kidney Injury Duration for Predicting Readmission?The Annals of thoracic surgery · 2019Article
- Cardiac and Vascular Surgery-Associated Acute Kidney Injury: The 20th International Consensus Conference of the ADQI (Acute Disease Quality Initiative) Group.Journal of the American Heart Association · 2018Review
- Pre-admission proteinuria impacts risk of non-recovery after dialysis-requiring acute kidney injury.Kidney international · 2018Article
- Acute kidney injury is a risk factor for subsequent proteinuria.Kidney international · 2018Observational
- Development of biomarker combinations for postoperative acute kidney injury via Bayesian model selection in a multicenter cohort study.Biomarker research · 2018Article
- Urinary Matrix Metalloproteinase-7 Predicts Severe AKI and Poor Outcomes after Cardiac Surgery.Journal of the American Society of Nephrology : JASN · 2017Article
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9 authors.
Funding
Abstract
BACKGROUND AND
objectivesPreoperative proteinuria is associated with a higher incidence of postoperative AKI. Whether the same is true for postoperative proteinuria is uncertain. This study tested the hypothesis that increased proteinuria after cardiac surgery is associated with an increased risk for AKI. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This prospective cohort study included 1198 adults undergoing cardiac surgery at six hospitals between July 2007 and December 2009. Albuminuria, urine albumin-to-creatinine ratio (ACR), and dipstick proteinuria were measured 0-6 hours after surgery. The primary outcome was AKI, defined as a doubling in serum creatinine or receipt of acute dialysis during the hospital stay. Analyses were adjusted for patient characteristics, including preoperative albuminuria.
resultsCompared with the lowest quintile, the highest quintile of albuminuria and highest grouping of dipstick proteinuria were associated with greatest risk for AKI (adjusted relative risks [RRs], 2.97 [95% confidence interval (CI), 1.20-6.91] and 2.46 [95% CI, 1.16-4.97], respectively). Higher ACR was not associated with AKI risk (highest quintile RR, 1.66 [95% CI, 0.68-3.90]). Of the three proteinuria measures, early postoperative albuminuria improved the prediction of AKI to the greatest degree (clinical model area under the curve, 0.75; 0.81 with albuminuria). Similar improvements with albuminuria were seen for net reclassification index (0.55; P<0.001) and integrated discrimination index (0.036; P<0.001).
conclusionsHigher levels of proteinuria after cardiac surgery identify patients at increased risk for AKI during their hospital stay.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.