ArticleToxicological sciences : an official journal of the Society of Toxicology2013
CTNNA3 (α-catenin) gene variants are associated with diisocyanate asthma: a replication study in a Caucasian worker population.
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- The genetics of occupational asthma development among workers exposed to diisocyanates: A systematic literature review with meta-analysis.Frontiers in genetics · 2022Pooled it
- Genetic architecture of suicidal ideation continuum: latent profile analysis of data using the million veteran program cohort.Molecular psychiatry · 2026Article
- Chromosome 21 variants tied to severe asthma exacerbations: A genome-wide association study in a Brazilian population.The journal of allergy and clinical immunology. Global · 2025Article
- Alpha-T-catenin is expressed in peripheral nerves as a constituent of Schwann cell adherens junctions.Biology open · 2022Article
- Influence of Genetic Variance on Biomarker Levels After Occupational Exposure to 1,6-Hexamethylene Diisocyanate Monomer and 1,6-Hexamethylene Diisocyanate Isocyanurate.Frontiers in genetics · 2020Article
- Clinical Implications of Single Nucleotide Polymorphisms in Diagnosis of Asthma and its Subtypes.Yonsei medical journal · 2019Review
- Genetic variants with gene regulatory effects are associated with diisocyanate-induced asthma.The Journal of allergy and clinical immunology · 2018Article
- Identification of differentially expressed genes associated with asthma in children based on the bioanalysis of the regulatory network.Molecular medicine reports · 2018Article
- Opportunities and obstacles in translating evidence to policy in occupational asthma.Annals of epidemiology · 2018Article
- αT-catenin: A developmentally dispensable, disease-linked member of the α-catenin family.Tissue barriers · 2018Review
- Cardiomyocytes of the Heart and Pulmonary Veins: Novel Contributors to Asthma?American journal of respiratory cell and molecular biology · 2017Review
- Usefulness of Biomarkers in Work-Related Airway Disease.Current treatment options in allergy · 2017Review
- Biomarkers in Occupational Asthma.Current allergy and asthma reports · 2016Review
- The cardiomyocyte protein αT-catenin contributes to asthma through regulating pulmonary vein inflammation.The Journal of allergy and clinical immunology · 2016Article
- Probabilistic models of genetic variation in structured populations applied to global human studies.Bioinformatics (Oxford, England) · 2016Article
- Do Low Molecular Weight Agents Cause More Severe Asthma than High Molecular Weight Agents?PloS one · 2016Article
- CTNNA3 and SEMA3D: Promising loci for asthma exacerbation identified through multiple genome-wide association studies.The Journal of allergy and clinical immunology · 2015Article
- Genome-Wide Association Study Identifies Novel Loci Associated With Diisocyanate-Induced Occupational Asthma.Toxicological sciences : an official journal of the Society of Toxicology · 2015Article
- New functions for alpha-catenins in health and disease: from cancer to heart regeneration.Cell and tissue research · 2015Review
- Gene-environment interaction from international cohorts: impact on development and evolution of occupational and environmental lung and airway disease.Seminars in respiratory and critical care medicine · 2015Review
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Authors and funding
17 authors at 9 institutions in 3 countries.
Funding
Abstract
Recently, a genome-wide association study (GWAS) conducted in Korean subjects identified four CTNNA3 (alpha-T catenin) single nucleotide polymorphisms (SNPs) (rs10762058, rs7088181, rs1786929, and rs4378283) associated with diisocyanate-induced occupational asthma (DA). The CTNNA3 gene codes for a cadherin involved in formation of stretch-resistant cell-cell adhesions. We conducted a candidate gene association study to replicate these findings in Caucasian workers. Genotyping was performed on DNA using a 5' nuclease PCR assay collected from 410 diisocyanate-exposed and predominantly Canadian workers including 132 workers with DA confirmed by a specific inhalation challenge (DA+); 131 symptomatic workers in whom DA was excluded by a negative challenge (DA-); and 147 hexamethylene diisocyanate-exposed asymptomatic workers (AWs). As in the Korean study, highly linked CTNNA3 rs7088181 and rs10762058 SNPs (but not rs4378283 and rs1786929) were significantly associated with DA+ when compared with AWs but not in comparison with DA- workers (p ≤ 0.05). After adjusting for potentially confounding variables of age, smoking status, and duration of exposure, minor allele homozygotes of rs7088181 and rs10762058 SNPs were at increased risk for DA compared with AWs (OR = 9.05 [95% CI: 1.69, 48.54] and OR = 6.82 [95% CI: 1.65, 28.24], respectively). In conclusion, we replicated results from the only reported GWAS study of DA demonstrating an association between two closely linked CTNNA3 gene SNPs and DA. These findings lend further support to the clinical relevance of these genotypes in predicting susceptibility to DA and the potential importance of catenins in the disease process.
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