ArticleJournal of medical microbiology2012
Genetic characteristics of drug-resistant Vibrio cholerae O1 causing endemic cholera in Dhaka, 2006-2011.
Article in Journal of medical microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Guidelines for the management of paediatric cholera infection: a systematic review of the evidence.Paediatrics and international child health · 2018Pooled it
- Molecular characterization ofIJID regions · 2026Article
- Genomic epidemiology of Vibrio cholerae during a mass vaccination campaign of displaced communities in Bangladesh.Nature communications · 2023Article
- Vibrio cholerae O1 associated with recent endemic cholera shows temporal changes in serotype, genotype, and drug-resistance patterns in Bangladesh.Gut pathogens · 2023Article
- Resistance ofFrontiers in pharmacology · 2023Review
- Difference of Phenotype and Genotype Between Human and Environmental: IsolatedIndian journal of microbiology · 2020Article
- Characterisation ofThe Pan African medical journal · 2020Article
- Novel Cholera Toxin Variant and ToxT Regulon in EnvironmentalApplied and environmental microbiology · 2019Article
- Speciation, clinical profile & antibiotic resistance inThe Indian journal of medical research · 2017Article
- Article
- Observed Handwashing with Soap Practices Among Cholera Patients and Accompanying Household Members in a Hospital Setting (CHoBI7 Trial).The American journal of tropical medicine and hygiene · 2016Article
- Transmission of InfectiousFrontiers in microbiology · 2016Article
- Vibrio cholerae Serogroup O139: Isolation from Cholera Patients and Asymptomatic Household Family Members in Bangladesh between 2013 and 2014.PLoS neglected tropical diseases · 2015Article
- The increased severity in patients presenting to hospital with diarrhea in Dhaka, Bangladesh since the emergence of the hybrid strain of Vibrio cholerae O1 is not unique to cholera patients.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2015Article
- The Dynamics of Genetic Interactions between Vibrio metoecus and Vibrio cholerae, Two Close Relatives Co-Occurring in the Environment.Genome biology and evolution · 2015Article
- Bacterial shedding in household contacts of cholera patients in Dhaka, Bangladesh.The American journal of tropical medicine and hygiene · 2014Article
- Cholera outbreaks (2012) in three districts of Nepal reveal clonal transmission of multi-drug resistant Vibrio cholerae O1.BMC infectious diseases · 2014Article
- Human impact on the microbiological water quality of the rivers.Journal of medical microbiology · 2013Review
- Vibrio cholerae O1 El Tor and O139 Bengal strains carrying ctxB(ET), Bangladesh.Emerging infectious diseases · 2013Article
- Article
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11 authors at 3 institutions in 3 countries.
Funding
Abstract
Vibrio cholerae O1 biotype El Tor (ET), causing the seventh cholera pandemic, was recently replaced in Bangladesh by an altered ET possessing ctxB of the Classical (CL) biotype, which caused the first six cholera pandemics. In the present study, V. cholerae O1 strains associated with endemic cholera in Dhaka between 2006 and 2011 were analysed for major phenotypic and genetic characteristics. Of 54 representative V. cholerae isolates tested, all were phenotypically ET and showed uniform resistance to trimethoprim/sulfamethoxazole (SXT) and furazolidone (FR). Resistance to tetracycline (TE) and erythromycin (E) showed temporal fluctuation, varying from year to year, while all isolates were susceptible to gentamicin (CN) and ciprofloxacin (CIP). Year-wise data revealed erythromycin resistance to be 33.3 % in 2006 and 11 % in 2011, while tetracycline resistance accounted for 33, 78, 0, 100 and 27 % in 2006, 2007, 2008, 2009 and 2010, respectively; interestingly, all isolates tested were sensitive to TE in 2011, as observed in 2008. All V. cholerae isolates tested possessed genetic elements such as SXT, ctxAB, tcpA(ET), rstR(ET) and rtxC; none had IntlI (Integron I). Double mismatch amplification mutation assay (DMAMA)-PCR followed by DNA sequencing and analysis of the ctxB gene revealed a point mutation at position 58 (C→A), which has resulted in an amino acid substitution from histidine (H) to asparagine (N) at position 20 (genotype 7) since 2008. Although the multi-resistant strains having tetracycline resistance showed minor genetic divergence, V. cholerae strains were clonal, as determined by a PFGE (NotI)-based dendrogram. This study shows 2008-2010 to be the time of transition from ctxB genotype 1 to genotype 7 in V. cholerae ET causing endemic cholera in Dhaka, Bangladesh.
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