ArticleChemistry & biodiversity2012
Nitric oxide (NO)-induced death of gram-negative bacteria from a light-controlled NO-releasing platform.
Article in Chemistry & biodiversity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 18 citations in OpenAlex.
- Nitric oxide-releasing antibacterial albumin plastic for biomedical applications.Journal of biomedical materials research. Part A · 2018Article
- Photocontrol of Antibacterial Activity: Shifting from UV to Red Light Activation.Journal of the American Chemical Society · 2017Article
- A multi-defense strategy: Enhancing bactericidal activity of a medical grade polymer with a nitric oxide donor and surface-immobilized quaternary ammonium compound.Acta biomaterialia · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
A NO-delivery platform has been fabricated from polydimethylsiloxane (PDMS) and Pluronic(®) F127 gel that contains the light-sensitive NO donor, [Mn(PaPy(3))(NO)]ClO(4). The material was assembled layer-by-layer. First, a thin PDMS membrane was cast. It was then layered with cold 25% (w/v) Pluronic(®) F127 gel mixed with [Mn(PaPy(3))(NO)]ClO(4). Finally, it was covered with a thick layer (nearly impermeable to NO) of PDMS (=polydimethoxysiloxane) to allow release of NO only from the thinner side upon exposure to light. Light-induced NO release from this layered material has been confirmed via NO-specific electrode and by a modified soft Griess-agar assay. Incorporation of ca. 8 mg/g of [Mn(PaPy(3))(NO)]ClO(4) in the Pluronic gel layer affords a material that drastically reduces the microbial loads of Acinetobacter baumannii and Pseudomonas aeruginosa via the antibiotic effects of the photoreleased NO. Application of this flexible layered NO-donating composite as bandage material has been proposed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.