ArticleChemistry & biodiversity2012
Molecular evolution, structure, and function of peroxidasins.
Article in Chemistry & biodiversity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 59 citations in OpenAlex.
- Comment on 'Oxidative Stress-Induced Expression Levels of PXDN and NF-κB in Type 2 Diabetic Patients With Nephropathy'.Endocrinology, diabetes & metabolism · 2026Article
- Peroxidasin is required for full viability in development and for maintenance of tissue mechanics in adults.Matrix biology : journal of the International Society for Matrix Biology · 2024Article
- Review of cancer cell volatile organic compounds: their metabolism and evolution.Frontiers in molecular biosciences · 2024Review
- Peroxidasin Inhibition by Phloroglucinol and Other Peroxidase Inhibitors.Antioxidants (Basel, Switzerland) · 2023Article
- Identification and characterization of two salmon louse heme peroxidases and their potential as vaccine antigens.iScience · 2023Article
- Found in translation-Fibrosis in metabolic dysfunction-associated steatohepatitis (MASH).Science translational medicine · 2023Review
- Halogenation Activity of Mammalian Heme Peroxidases.Antioxidants (Basel, Switzerland) · 2022Review
- Peroxidasin Deficiency Re-programs Macrophages Toward Pro-fibrolysis Function and Promotes Collagen Resolution in Liver.Cellular and molecular gastroenterology and hepatology · 2022Article
- Western Diet Induced Remodelling of the Tongue Proteome.Proteomes · 2021Article
- Inhibition of Myeloperoxidase.Handbook of experimental pharmacology · 2021Article
- Genome-enabled insights into the biology of thrips as crop pests.BMC biology · 2020Article
- Peroxidasin mediates bromination of tyrosine residues in the extracellular matrix.The Journal of biological chemistry · 2020Article
- Heme-Peroxidase 2, a Peroxinectin-Like Gene, Regulates Bacterial Homeostasis inFrontiers in physiology · 2020Article
- DSS-induced damage to basement membranes is repaired by matrix replacement and crosslinking.Journal of cell science · 2019Article
- Inhibitory Anti-Peroxidasin Antibodies in Pulmonary-Renal Syndromes.Journal of the American Society of Nephrology : JASN · 2018Article
- Peroxidasin-mediated crosslinking of collagen IV is independent of NADPH oxidases.Redox biology · 2018Article
- Neurogenomic Signatures of Successes and Failures in Life-History Transitions in a Key Insect Pollinator.Genome biology and evolution · 2017Article
- Role of Hypohalous Acids in Basement Membrane Homeostasis.Antioxidants & redox signaling · 2017Review
- Pre-steady-state Kinetics Reveal the Substrate Specificity and Mechanism of Halide Oxidation of Truncated Human Peroxidasin 1.The Journal of biological chemistry · 2017Article
- pxn-1 and pxn-2 May Interact Negatively during Neuronal Development and Aging in C. elegans.Molecules and cells · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Peroxidasins represent the subfamily 2 of the peroxidase-cyclooxygenase superfamily and are closely related to chordata peroxidases (subfamily 1) and peroxinectins (subfamily 3). They are multidomain proteins containing a heme peroxidase domain with high homology to human lactoperoxidase that mediates one- and two-electron oxidation reactions. Additional domains of the secreted and glycosylated metalloproteins are type C-like immunoglobulin domains, typical leucine-rich repeats, as well as a von Willebrand factor C module. These are typical motifs of extracellular proteins that mediate protein-protein interactions. We have reconstructed the phylogeny of this new family of oxidoreductases and show the presence of four invertebrate clades as well as one vertebrate clade that includes also two different human representatives. The variability of domain assembly in the various clades was analyzed, as was the occurrence of relevant catalytic residues in the peroxidase domain based on the knowledge of catalysis of the mammalian homologues. Finally, the few reports on expression, localization, enzymatic activity, and physiological roles in the model organisms Drosophila melanogaster, Caenorhabditis elegans, and Homo sapiens are critically reviewed. Roles attributed to peroxidasins include antimicrobial defense, extracellular matrix formation, and consolidation at various developmental stages. Many research questions need to be solved in future, including detailed biochemical/physical studies and elucidation of the three dimensional structure of a model peroxidasin as well as the relation and interplay of the domains and the in vivo functions in various organisms including man.
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