ArticleJournal of gastroenterology2013
Association between metabolic syndrome and prevalence of gastroesophageal reflux disease in a health screening facility in Japan.
Article in Journal of gastroenterology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Pooled it
- Effects of acotiamide on esophageal motor function and gastroesophageal reflux in healthy volunteers.BMC gastroenterology · 2015Trial
- Relationship between metabolic syndrome-related parameters and endoscopic classification of gastroesophageal reflux disease: a Japanese health checkup cohort study.Esophagus : official journal of the Japan Esophageal Society · 2026Article
- Prevalence and Risk Factors of Gastroesophageal Reflux Disease in Patients with Dyspeptic and Reflux Symptoms: An Endoscopy-Based Prospective Study from Al Khobar, Saudi Arabia.Journal of epidemiology and global health · 2025Observational
- Metabolic syndrome is associated with gastroesophageal reflux disease in a large Taiwanese population study.International journal of medical sciences · 2025Article
- Novel Endoscopic Findings of Lesions with a Short White Hair-like Appearance in the Lower Esophagus.Internal medicine (Tokyo, Japan) · 2024Article
- Immunoglobulin G-mediated food intolerance and metabolic syndrome influence the occurrence of reflux esophagitis inWorld journal of gastroenterology · 2024Article
- The pathogenesis of post-stroke osteoporosis and the role oxidative stress plays in its development.Frontiers in medicine · 2023Review
- Endoscopic findings of cardiac lymphoid hyperplasia andDEN open · 2022Article
- Predictive Factors for Future Onset of Reflux Esophagitis: A Longitudinal Case-control Study Using Health Checkup Records.Journal of neurogastroenterology and motility · 2022Article
- Metabolic Dysfunction-Associated Fatty Liver Disease Increases the Risk of Gastroesophageal Reflux Symptoms.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- Proton-pump inhibitors associated with decreased urinary citrate excretion.International urology and nephrology · 2021Article
- Prevalence of Barrett's Epithelium Shown by Endoscopic Observations with Linked Color Imaging in Subjects with Different H. pylori Infection Statuses.Internal medicine (Tokyo, Japan) · 2021Article
- Association between Gastroesophageal Reflux Disease and Elastographic Parameters of Liver Steatosis and Fibrosis: Controlled Attenuation Parameter and Liver Stiffness Measurements.Canadian journal of gastroenterology & hepatology · 2021Article
- The association between metabolic syndrome and erosive esophagitis: A systematic review and meta-analysis.EXCLI journal · 2021Review
- Clinical features and therapeutic responses to proton pump inhibitor in patients with severe reflux esophagitis: A multicenter prospective observational study.JGH open : an open access journal of gastroenterology and hepatology · 2021Article
- Metabolically Healthy Obesity and the Risk of Erosive Esophagitis: A Cohort Study.Clinical and translational gastroenterology · 2019Article
- Barretts's carcinogenesis.Pathology international · 2019Article
- What is the impact of metabolic syndrome and its components on reflux esophagitis? A cross-sectional study.BMC gastroenterology · 2019Article
- Recent Topics and Perspectives on Esophageal Cancer in Japan.JMA journal · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAbdominal fat accumulation, which induces high intra-abdominal pressure that causes increase in the gastroesophageal pressure gradient and hiatal hernia, as well as obesity, has been shown to increase the prevalence of gastroesophageal reflux disease (GERD). This study was performed to clarify the association between metabolic syndrome and the prevalence of GERD.
methodsThe study subjects were an adult population who visited a medical center for annual medical check-ups from April 2010 to March 2011. GERD was diagnosed by the presence of endoscopically proven reflux esophagitis, GERD symptoms (QUEST score ≥6), or current medical therapy for GERD. The presence of metabolic or pre-metabolic syndrome was diagnosed based on the Japanese criteria for metabolic syndrome.
resultsSix hundred four (16.0 %) of 3775 study subjects were positively diagnosed with GERD, with the number of those with metabolic and pre-metabolic syndrome being 477 (12.6 %) and 384 (10.2 %), respectively. Multiple logistic regression analysis showed that male gender, presence of hiatal hernia, and metabolic or pre-metabolic syndrome, as well as absence of gastric mucosal atrophy, were significant predictive factors for the prevalence of GERD, as were visceral fat accumulation and untreated dyslipidemia. Untreated hypertension and untreated hyperglycemia were also considered to be positive risk factors. Subjects undergoing treatment for hypertension showed an increased risk of GERD, while those undergoing treatment for dyslipidemia and diabetes mellitus showed a decreased risk.
conclusionMetabolic syndrome is a reliable predictive factor for the prevalence of GERD, and medical therapy for metabolic syndrome may modify the risk of GERD occurrence.
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