ArticleJournal of neural engineering2012
Facilitation and restoration of cognitive function in primate prefrontal cortex by a neuroprosthesis that utilizes minicolumn-specific neural firing.
Article in Journal of neural engineering, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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Who cites it
42 citing papers in PubMed, 102 citations in OpenAlex.
- Advancing neuroengineering with Neuromorphic Twins.Nature communications · 2026Review
- Electrode Arrays for Detecting and Modulating Deep Brain Neural Information in Primates: A Review.Cyborg and bionic systems (Washington, D.C.) · 2025Review
- Neuromorphic-Based Neuroprostheses for Brain Rewiring: State-of-the-Art and Perspectives in Neuroengineering.Brain sciences · 2022Review
- Plasticity and Adaptation in Neuromorphic Biohybrid Systems.iScience · 2020Review
- Delaying memory decline: different options and emerging solutions.Translational psychiatry · 2020Review
- Human enhancement through the lens of experimental and speculative neurotechnologies.Human behavior and emerging technologies · 2019Article
- Glial responses to implanted electrodes in the brain.Nature biomedical engineering · 2017Article
- A cognitive prosthesis for memory facilitation by closed-loop functional ensemble stimulation of hippocampal neurons in primate brain.Experimental neurology · 2017Article
- What Is the Evidence for Inter-laminar Integration in a Prefrontal Cortical Minicolumn?Frontiers in neuroanatomy · 2017Article
- Connecting the Brain to Itself through an Emulation.Frontiers in neuroscience · 2017Article
- Neural Substrate Expansion for the Restoration of Brain Function.Frontiers in systems neuroscience · 2016Review
- The Structural and Functional Organization of Cognition.Frontiers in human neuroscience · 2016Article
- Qualitative-Modeling-Based Silicon Neurons and Their Networks.Frontiers in neuroscience · 2016Review
- Restoring Behavior via Inverse Neurocontroller in a Lesioned Cortical Spiking Model Driving a Virtual Arm.Frontiers in neuroscience · 2016Article
- Hippocampal closed-loop modeling and implications for seizure stimulation design.Journal of neural engineering · 2015Article
- Neurons and networks organizing and sequencing memories.Brain research · 2015Article
- Identification of functional synaptic plasticity from spiking activities using nonlinear dynamical modeling.Journal of neuroscience methods · 2015Article
- Prefrontal cortical recordings with biomorphic MEAs reveal complex columnar-laminar microcircuits for BCI/BMI implementation.Journal of neuroscience methods · 2015Article
- A neuro-inspired model-based closed-loop neuroprosthesis for the substitution of a cerebellar learning function in anesthetized rats.Scientific reports · 2015Article
- Model-based asessment of an in-vivo predictive relationship from CA1 to CA3 in the rodent hippocampus.Journal of computational neuroscience · 2015Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveMaintenance of cognitive control is a major concern for many human disease conditions; therefore, a major goal of human neuroprosthetics is to facilitate and/or recover the cognitive function when such circumstances impair appropriate decision making. APPROACH: Minicolumnar activity from the prefrontal cortex (PFC) was recorded from nonhuman primates trained to perform a delayed match to sample (DMS), via custom-designed conformal multielectrode arrays that provided inter-laminar recordings from neurons in the PFC layer 2/3 and layer 5. Such recordings were analyzed via a previously demonstrated nonlinear multi-input-multi-output (MIMO) neuroprosthesis in rodents, which extracted and characterized multicolumnar firing patterns during DMS performance. MAIN
resultsThe MIMO model verified that the conformal recorded individual PFC minicolumns responded to entrained target selections in patterns critical for successful DMS performance. This allowed the substitution of task-related layer 5 neuron firing patterns with electrical stimulation in the same recording regions during columnar transmission from layer 2/3 at the time of target selection. Such stimulation improved normal task performance, but more importantly, recovered performance when applied as a neuroprosthesis following the pharmacological disruption of decision making in the same task. SIGNIFICANCE: These findings provide the first successful application of neuroprosthesis in the primate brain designed specifically to restore or repair the disrupted cognitive function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.