Evidence map›Paper›PMID 22976427›Full record

ReviewJournal of assisted reproduction and genetics2012

Assessment and treatment of repeated implantation failure (RIF).

Alex Simon, Neri Laufer

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of assisted reproduction and genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02681367 (The First Study to Compare the Effect of Freeze All Policy Versus Fresh Embryo Transfer After ICSI in Patients With Recurrent Implantation Failure), which is not on this map. Cited by 111 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
111citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02681367 nacompletednot on this map

The First Study to Compare the Effect of Freeze All Policy Versus Fresh Embryo Transfer After ICSI in Patients With Recurrent Implantation Failure

TypeinterventionalSponsorTopLab Company for ART Laboratories Consultation and TrainingRan2012 to 2016Enrolled200ConditionsRecurrent Implantation Failure (RIF)ArmsFreeze all policy
3 · Its place in the literature

Who cites it

111 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Interventions for recurrent embryo implantation failure: An umbrella review.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
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  18. Platelet-rich plasma versus granulocyte colony-stimulating factor in addressing recurrent implantation failure: A randomized, double-blind clinical trial.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2026
    Article
  19. Article
  20. HLA-G, IL-6 and TGF-β in Seminal Plasma as Potential Biomarkers of ART Outcome.American journal of reproductive immunology (New York, N.Y. : 1989) · 2025
    Article

51 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Alex SimonDepartment of Obstetrics and Gynecology, In Vitro Fertilization Unit, Ein Kerem, Hebrew University, Hadassah Medical Center, POB 12000, Jerusalem, 91120, Israel. simonal@hadassah.org.il
Neri Laufer

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Repeated implantation failure (RIF) is determined when embryos of good quality fail to implant following several in vitro fertilization (IVF) treatment cycles. Implantation failure is related to either maternal factors or embryonic causes. Maternal factors include uterine anatomic abnormalities, thrombophilia, non-receptive endometrium and immunological factors. Failure of implantation due to embryonic causes is associated with either genetic abnormalities or other factors intrinsic to the embryo that impair its ability to develop in utero, to hatch and to implant. New methods of time-lapse imaging of embryos and assessment of their metabolic functions may improve selection of embryos for transfer, and subsequent outcomes for IVF patients, as well as for those diagnosed with RIF. This review discusses the various causes associated with RIF and addresses appropriate treatments.

Indexed as

Embryo ImplantationEmbryo, MammalianFemaleFertilization in VitroHumansInfertility, FemaleRecurrenceTreatment Failure

Identifiers

PMID22976427
PMCPMC3510376

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.