ArticleJournal of Alzheimer's disease : JAD2013
Plasma amyloid-β levels and prognosis in incident dementia cases of the 3-City Study.
Article in Journal of Alzheimer's disease : JAD, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Plasma and cerebrospinal fluid amyloid-β levels in late-life depression: A systematic review and meta-analysis.Journal of psychiatric research · 2015Pooled it
- Network Meta-Analysis of Cognitive Impairment and miRNA Expression in Alzheimer's Disease Patients with Hearing Loss: A Systematic Review and Cross-Validation.Journal of clinical medicine · 2026Review
- Sleep and geriatric syndromes in elderly emergency patients in China: a cross-sectional survey.PeerJ · 2025Article
- Integrating Demographics and Imaging Features for Various Stages of Dementia Classification: Feed Forward Neural Network Multi-Class Approach.Biomedicines · 2024Article
- Plasma oligomer beta-amyloid is associated with disease severity and cerebral amyloid deposition in Alzheimer's disease spectrum.Alzheimer's research & therapy · 2024Article
- Complaints of daytime sleepiness, insomnia, hypnotic use, and risk of dementia: a prospective cohort study in the elderly.Alzheimer's research & therapy · 2022Article
- Serum Tau Proteins as Potential Biomarkers for the Assessment of Alzheimer's Disease Progression.International journal of molecular sciences · 2020Article
- Non-linear Relationship Between Plasma Amyloid-β 40 Level and Cognitive Decline in a Cognitively Normal Population.Frontiers in aging neuroscience · 2020Article
- Validation of Immunoassay-Based Tools for the Comprehensive Quantification of Aβ40 and Aβ42 Peptides in Plasma.Journal of Alzheimer's disease : JAD · 2016Article
- The Alzheimer's disease peptide β-amyloid promotes thrombin generation through activation of coagulation factor XII.Journal of thrombosis and haemostasis : JTH · 2016Article
- Palmomental Reflex a Relevant Sign in Early Alzheimer's Disease Diagnosis?Journal of Alzheimer's disease : JAD · 2016Article
- Activation of the factor XII-driven contact system in Alzheimer's disease patient and mouse model plasma.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Effect of stent-assisted angioplasty on cognitive status and serum levels of amyloid beta in patients with intracranial and/or extracranial artery stenosis.Neuropsychiatric disease and treatment · 2015Article
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Authors and funding
11 authors.
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Abstract
Studies of plasma amyloid-β (Aβ) levels as potential biomarkers for incident Alzheimer's disease (AD) have yielded contradictory results. We explored the associations between plasma Aβ(40), Aβ(42), and truncated Aβ levels, and prognosis of dementia in participants of the prospective 3-City Study. 120 aged individuals diagnosed with 2-year incident dementia were followed up for seven years. The associations between Aβ plasma levels and baseline cognitive score, cognitive decline, and death were examined. A higher level of baseline plasma Aβ was associated with worse cognitive status two years prior to incident dementia diagnosis. In incident AD patients, the association was only significant for Aβ(40) and Aβ(n-42). In the fast cognitive decliners group, especially in AD cases, a higher level of 5 pg/ml of baseline Aβ(42), Aβ(n-42), Aβ(n-42)/Aβ(n-40), and Aβ(42)/Aβ(40) ratios were associated with a lower risk of fast cognitive decline based on the Isaacs Set Test score. There was no association between peptide levels and mortality in demented subjects. When assayed at prodromal stage, plasma Aβ levels may be potentially useful markers of fast cognitive decline in individuals who subsequently become demented.
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