ArticleGene2012
Leptin and leptin receptor genetic variants associate with habitual physical activity and the arm body composition response to resistance training.
Article in Gene, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Heterogeneity in resistance training-induced muscle strength and mass responses in men and women of different ages.Age (Dordrecht, Netherlands) · 2016Trial
- Obesity and Exercise: New Insights and Perspectives.Endocrine reviews · 2025Review
- Low leptin levels are associated with elevated physical activity among lean school children in rural Tanzania.BMC public health · 2022Article
- Restlessness and an Increased Urge to Move (Drive for Activity) in Anorexia Nervosa May Strengthen Personal Motivation to Maintain Caloric Restriction and May Augment Body Awareness and Proprioception: A Lesson From Leptin Administration in Anorexia Nervosa.Frontiers in psychology · 2022Review
- An intron variant of the GLI family zinc finger 3 (GLI3) gene differentiates resistance training-induced muscle fiber hypertrophy in younger men.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Physical Exercise: An Overview of Benefits From Psychological Level to Genetics and Beyond.Frontiers in physiology · 2021Review
- Article
- Genetic variants associated with exercise performance in both moderately trained and highly trained individuals.Molecular genetics and genomics : MGG · 2020Article
- Greater Reduction in Abdominal Than in Upper Arms Subcutaneous Fat in 10- to 12-Year-Old Tennis Players: A Volumetric MRI Study.Frontiers in pediatrics · 2019Article
- Association between gene polymorphisms and obesity and physical fitness in Korean children.Biology of sport · 2018Article
- Associations of TNF-α and IL-6 polymorphisms with osteoporosis through joint effects and interactions with LEPR gene in Taiwan: Taichung Community Health Study for Elders (TCHS-E).Molecular biology reports · 2016Article
- Genetic variants influencing effectiveness of exercise training programmes in obesity - an overview of human studies.Biology of sport · 2016Review
- Neonatal leptin deficiency reduces frontal cortex volumes and programs adult hyperactivity in mice.Behavioural brain research · 2014Article
- Highlights from the functional single nucleotide polymorphisms associated with human muscle size and strength or FAMuSS study.BioMed research international · 2013Article
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Authors and funding
17 authors at 11 institutions in 2 countries.
Funding
Abstract
purposeWe investigated the influence of Leptin (LEP) and leptin receptor (LEPR) SNPs on habitual physical activity (PA) and body composition response to a unilateral, upper body resistance training (RT) program.
methodsEuropean-derived American volunteers (men=111, women=131, 23.4 ± 5.4 yr, 24.4 ± 4.6 kg·m(-2)) were genotyped for LEP 19 G>A (rs2167270), and LEPR 326 A>G (rs1137100), 668 A>G (rs1137101), 3057 G>A (rs1805096), and 1968 G>C (rs8179183). They completed the Paffenbarger PA Questionnaire. Arm muscle and subcutaneous fat volumes were measured before and after 12 wk of supervised RT with MRI. Multivariate and repeated measures ANCOVA tested differences among phenotypes by genotype and gender with age and body mass index as covariates.
resultsAdults with the LEP 19 GG genotype reported more kcal/wk in vigorous intensity PA (1273.3 ± 176.8, p=0.017) and sports/recreation (1922.8 ± 226.0, p<0.04) than A allele carriers (718.0 ± 147.2, 1328.6 ± 188.2, respectively). Those with the LEP 19 GG genotype spent more h/wk in light intensity PA (39.7 ± 1.6) than A allele carriers (35.0 ± 1.4, p=0.03). In response to RT, adults with the LEPR 668 G allele gained greater arm muscle volume (67,687.05 ± 3186.7 vs. 52,321.87 ± 5125.05 mm(3), p=0.01) and subcutaneous fat volume (10,599.89 ± 3683.57 vs. -5224.73 ± 5923.98 mm(3), p=0.02) than adults with the LEPR 668 AA genotype, respectively.
conclusionLEP19 G>A and LEPR 668 A>G associated with habitual PA and the body composition response to RT. These LEP and LEPR SNPs are located in coding exons likely influencing LEP and LEPR function. Further investigation is needed to confirm our findings and establish mechanisms for LEP and LEPR genotype and PA and body composition associations we observed.
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