ArticleDevelopmental cell2012
Radial construction of an arterial wall.
Article in Developmental cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed.
- A Comprehensive Review of Epigenetic Regulation of Vascular Smooth Muscle Cells During Development and Disease.Biomolecules · 2026Review
- Loss ofAmerican journal of respiratory cell and molecular biology · 2025Article
- Origins of Aortic Coarctation: A Vascular Smooth Muscle Compartment Boundary Model.Journal of developmental biology · 2025Article
- High-parametric protein maps reveal the spatial organization in early-developing human lung.Nature communications · 2024Article
- Evaluation of Antibodies for Vascular Smooth Muscle Cell Characterization.Stem cell and regenerative medicine (Wilmington, Del.) · 2024Article
- Cellular mechanisms of oligoclonal vascular smooth muscle cell expansion in cardiovascular disease.Cardiovascular research · 2023Article
- A topographic atlas defines developmental origins of cell heterogeneity in the human embryonic lung.Nature cell biology · 2023Article
- Mechanisms of fibrous cap formation in atherosclerosis.Frontiers in cardiovascular medicine · 2023Review
- The age of bone marrow dictates the clonality of smooth muscle-derived cells in atherosclerotic plaques.Nature aging · 2023Article
- Single-cell transcriptomics reveals skewed cellular communication and phenotypic shift in pulmonary artery remodeling.JCI insight · 2022Article
- Directing Multicellular Organization by Varying the Aspect Ratio of Soft Hydrogel Microwells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- p38 MAPK priming boosts VSMC proliferation and arteriogenesis by promoting PGC1α-dependent mitochondrial dynamics.Scientific reports · 2022Article
- Three-axis classification of mouse lung mesenchymal cells reveals two populations of myofibroblasts.Development (Cambridge, England) · 2022Article
- A census of the lung: CellCards from LungMAP.Developmental cell · 2022Article
- Decreased plasma levels of PDGF-BB, VEGF-A, and HIF-2α in preterm infants after ibuprofen treatment.Frontiers in pediatrics · 2022Article
- Mechanisms of vascular smooth muscle cell investment and phenotypic diversification in vascular diseases.Biochemical Society transactions · 2021Review
- Evidence for Multiple Origins of De Novo Formed Vascular Smooth Muscle Cells in Pulmonary Hypertension: Challenging the Dominant Model of Pre-Existing Smooth Muscle Expansion.International journal of environmental research and public health · 2021Review
- Simple model of atherosclerosis in cylindrical arteries: impact of anisotropic growth on Glagov remodeling.Mathematical medicine and biology : a journal of the IMA · 2021Article
- Article
- A Notch3-Marked Subpopulation of Vascular Smooth Muscle Cells Is the Cell of Origin for Occlusive Pulmonary Vascular Lesions.Circulation · 2020Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Some of the most serious diseases involve altered size and structure of the arterial wall. Elucidating how arterial walls are built could aid understanding of these diseases, but little is known about how concentric layers of muscle cells and the outer adventitial layer are assembled and patterned around endothelial tubes. Using histochemical, clonal, and genetic analysis in mice, here we show that the pulmonary artery wall is constructed radially, from the inside out, by two separate but coordinated processes. One is sequential induction of successive cell layers from surrounding mesenchyme. The other is controlled invasion of outer layers by inner layer cells through developmentally regulated cell reorientation and radial migration. We propose that a radial signal gradient controls these processes and provide evidence that PDGF-B and at least one other signal contribute. Modulation of such radial signaling pathways may underlie vessel-specific differences and pathological changes in arterial wall size and structure.
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