ReviewAnnual review of genetics2012
Dosage compensation of the sex chromosomes.
Review in Annual review of genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 135 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
135 citing papers in PubMed, 233 citations in OpenAlex.
- Widespread male-female expression imbalance of X-linked genes across phrynosomatid lizards.Molecular biology and evolution · 2026Article
- Escape from X inactivation drives sex differences in gene expression.Molecular biology and evolution · 2026Article
- Escape from X inactivation varies across genes and tissues and shapes sex-biased sex chromosome gene expression.BMC genomics · 2026Article
- Evolutionary Dynamics of Dosage Compensation and Sex-biased Gene Expression in Morabine Grasshopper Vandiemenella viatica.Genome biology and evolution · 2026Article
- Multiscale chromatin modeling of chromosome X structural changes upon inactivation highlights the differential regulatory mechanism ofbioRxiv : the preprint server for biology · 2026Article
- Chromatin dynamics of a large-sized genome provides insights into polyphenism and X0 dosage compensation of locusts.Nature genetics · 2025Article
- Xist condensates: perspectives for therapeutic intervention.Genome biology · 2025Review
- Contrasting Evolutionary Trajectories Under Paternal Genome Elimination in Male and Female Citrus Mealybugs.Molecular ecology · 2025Article
- Effect of heterozygous deletions on phenotypic changes and dosage compensation in Arabidopsis thaliana.Scientific reports · 2025Article
- Cross-species imputation and comparison of single-cell transcriptomic profiles.Genome biology · 2025Article
- Sex Chromosome Dosage Compensation in Insects.Insects · 2025Review
- Interactions between U and V sex chromosomes during the life cycle of Ectocarpus.Development (Cambridge, England) · 2024Article
- Cross-species imputation and comparison of single-cell transcriptomic profiles.bioRxiv : the preprint server for biology · 2024Article
- siRNA that participates in Drosophila dosage compensation is produced by many 1.688X and 359 bp repeats.Genetics · 2024Article
- The role of mitochondria in sex- and age-specific gene expression in a species without sex chromosomes.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Identification of X chromatin is modulated by complementary pathways in Drosophila melanogaster.G3 (Bethesda, Md.) · 2024Article
- Article
- Single-cell multiplex chromatin and RNA interactions in aging human brain.bioRxiv : the preprint server for biology · 2024Article
- The role of mitochondria in sex- and age-specific gene expression in a species without sex chromosomes.bioRxiv : the preprint server for biology · 2023Article
- Extensive Copy Number Variation Explains Genome Size Variation in the Unicellular Zygnematophycean Alga, Closterium peracerosum-strigosum-littorale Complex.Genome biology and evolution · 2023Article
75 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Differentiated sex chromosomes evolved because of suppressed recombination once sex became genetically controlled. In XX/XY and ZZ/ZW systems, the heterogametic sex became partially aneuploid after degeneration of the Y or W. Often, aneuploidy causes abnormal levels of gene expression throughout the entire genome. Dosage compensation mechanisms evolved to restore balanced expression of the genome. These mechanisms include upregulation of the heterogametic chromosome as well as repression in the homogametic sex. Remarkably, strategies for dosage compensation differ between species. In organisms where more is known about molecular mechanisms of dosage compensation, specific protein complexes containing noncoding RNAs are targeted to the X chromosome. In addition, the dosage-regulated chromosome often occupies a specific nuclear compartment. Some genes escape dosage compensation, potentially resulting in sex-specific differences in gene expression. This review focuses on dosage compensation in mammals, with comparisons to fruit flies, nematodes, and birds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.