ArticleInternational journal of experimental pathology2012
Vitamin C deficiency accelerates bone loss inducing an increase in PPAR-γ expression in SMP30 knockout mice.
Article in International journal of experimental pathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Pooled it
- Dietary vitamin C intake and the risk of hip fracture: a dose-response meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Pooled it
- Insights into vitamin C in musculoskeletal physiology and disorders: mechanisms and translational perspectives.Frontiers in immunology · 2026Review
- Vanadium Compound Treatment Modulates MC3t3-E1 Osteoblast Function.International journal of molecular sciences · 2025Article
- Role of vitamins beyond vitamin DInternational journal of molecular medicine · 2024Review
- The Functional Roles of Methionine and Arginine in Intestinal and Bone Health of Poultry: Review.Animals : an open access journal from MDPI · 2023Review
- Effect of ascorbic acid and epidermal growth factor in a rat tibia defect.Acta cirurgica brasileira · 2023Article
- Associations between Dietary Antioxidant Vitamin Intake and the Changes in Bone Mass in Chinese Adolescents: A 2.5-Year Longitudinal Study.Nutrients · 2022Article
- Evaluate the effects of serum urate level on bone mineral density: a genome-wide gene-environment interaction analysis in UK Biobank cohort.Endocrine · 2021Article
- Vitamin C Deficiency and the Risk of Osteoporosis in Patients with an Inflammatory Bowel Disease.Nutrients · 2020Review
- Bone Regeneration Induced by Strontium Folate Loaded Biohybrid Scaffolds.Molecules (Basel, Switzerland) · 2019Review
- Vitamin C Activates Osteoblastogenesis and Inhibits Osteoclastogenesis via Wnt/β-Catenin/ATF4 Signaling Pathways.Nutrients · 2019Article
- Osteoporosis, vitamin C intake, and physical activity in Korean adults aged 50 years and over.Journal of physical therapy science · 2016Article
- [Scurvy. A rare differential diagnosis of rheumatic diseases].Zeitschrift fur Rheumatologie · 2016Article
- The Roles and Mechanisms of Actions of Vitamin C in Bone: New Developments.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2015Review
- Favorable effect of dietary vitamin C on bone mineral density in postmenopausal women (KNHANES IV, 2009): discrepancies regarding skeletal sites, age, and vitamin D status.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015Article
- Effect of dietary ascorbic Acid on osteogenesis of expanding midpalatal suture in rats.Journal of dentistry (Tehran, Iran) · 2015Article
- Adipocytes as immune regulatory cells.International immunopharmacology · 2013Article
- Increased susceptibility of radiation-induced intestinal apoptosis in SMP30 KO mice.International journal of molecular sciences · 2013Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Senescence marker protein (SMP) 30 knockout (KO) mice display symptoms of scurvy, including spontaneous bone fractures, and this was considered to be induced by a failure of collagen synthesis owing to vitamin C deficiency. However, low bone mineral density is also known to be associated with spontaneous bone fracture. Therefore, we investigated the effects of vitamin C deficiency on the balance between osteoblasts and osteoclasts in SMP30 KO mice as evidenced by histopathology. All mice were fed a vitamin C-free diet, and only one group (KV) mice were given water containing 1.5 g/l of vitamin C, whereas wild-type (WT) and KO mice were given normal drinking tap water without vitamin C for 16 weeks. After 16 weeks, all femur samples were removed for histopathological examination. The femurs of KO mice showed significantly reduced bone area and decreased number of osteoblasts compared with those of WT mice and KV mice. KO mice also exhibited the lowest level of alkaline phosphatase (ALP) expression in their femurs. However, KO mice showed the most elevated expression of the receptor activator of nuclear factor kappa-B ligand (RANKL). Moreover, KO mice had the strongest peroxisome proliferator-activated receptor (PPAR)-γ expression level in their osteoblasts and the highest number of TUNEL-positive bone marrow cells. Therefore, we concluded that vitamin C deficiency plays an important role in spontaneous bone fracture by inhibiting osteoblast differentiation and promoting transition of osteoblasts to adipocytes, and this could in turn be related to the increased PPAR-γ expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.