ArticleBMC microbiology2012
Alterations of microbiota in urine from women with interstitial cystitis.
Article in BMC microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02232282 (Acupuncture for Female Interstitial Cystitis/Painful Bladder Syndrome and Its Effect on the Urinary Microbiome), which is not on this map. Cited by 127 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Acupuncture for Female Interstitial Cystitis/Painful Bladder Syndrome and Its Effect on the Urinary Microbiome: A Randomized Controlled Trial
Who cites it
127 citing papers in PubMed, 3 syntheses or guidelines pooled it, 223 citations in OpenAlex.
- The emerging role of the urinary microbiome in benign noninfectious urological conditions: an up-to-date systematic review.World journal of urology · 2023Pooled it
- Uncovering the role of urinary microbiota in urological tumors: a systematic review of literature.World journal of urology · 2022Pooled it
- The impact of microbiome in urological diseases: a systematic review.International urology and nephrology · 2019Pooled it
- Genomic relatedness and clinical significance ofMicrobial genomics · 2021Trial
- The urinary microbiota of men and women and its changes in women during bacterial vaginosis and antibiotic treatment.Microbiome · 2017Trial
- Alterations in urinary microbiota composition and function in men with Asthenozoospermia: a case-control study.Basic and clinical andrology · 2026Article
- The urinary microbiome, overactive bladder and bladder pain syndrome/interstitial cystitis - mechanisms, diagnostics and therapeutic opportunities.Nature reviews. Urology · 2026Review
- Urobiome Analysis in Interstitial Cystitis/Bladder Pain Syndrome Reveals Nuanced Differences Associated with Localized Pain.International urogynecology journal · 2026Article
- Development of the Urogenital Microbiota in Healthy Beagle Puppies: A Longitudinal Comparison with the Dam.Life (Basel, Switzerland) · 2026Article
- The microbiome of interstitial cystitis revealed by 2bRAD-M.Scientific reports · 2026Article
- Characterization and comparative analysis of urinary bacterial microbiome profiling in healthy cats and cats with feline idiopathic cystitis.Scientific reports · 2026Article
- Metagenomics and metabolomics analyses of the mechanism of non-expression of natural mating behavior in captive male Malayan pangolins (Frontiers in microbiology · 2026Article
- Article
- The urinary microbiome: the next frontier of bacterial ecology.Journal of bacteriology · 2025Review
- Long-Term Antibiotics for Disturbed Bladder Microbiome Disorders.International urogynecology journal · 2025Review
- A Pilot Study on the Impact of Cranberry and Ascorbic Acid Supplementation on the Urinary Microbiome of Healthy Women: A Randomized Controlled Trial.Antibiotics (Basel, Switzerland) · 2025Article
- Urinary microbiota changes among NMIBC patients during BCG therapy: comparing BCG responders and non-responders.Frontiers in cellular and infection microbiology · 2025Article
- An Overview of the Association of the Urinary Tract Microbiome with Various Diseases and Implications for Therapeutics.Mini reviews in medicinal chemistry · 2025Review
- Unique genital microbiota in male lichen sclerosus urethral stricture associated with urine exposure.BMC microbiology · 2024Article
- Metagenome-based microbial community analysis of urine-derived fertilizer.BMC microbiology · 2024Article
67 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInterstitial Cystitis (IC) is a chronic inflammatory condition of the bladder with unknown etiology. The aim of this study was to characterize the microbial community present in the urine from IC female patients by 454 high throughput sequencing of the 16S variable regions V1V2 and V6. The taxonomical composition, richness and diversity of the IC microbiota were determined and compared to the microbial profile of asymptomatic healthy female (HF) urine.
resultsThe composition and distribution of bacterial sequences differed between the urine microbiota of IC patients and HFs. Reduced sequence richness and diversity were found in IC patient urine, and a significant difference in the community structure of IC urine in relation to HF urine was observed. More than 90% of the IC sequence reads were identified as belonging to the bacterial genus Lactobacillus, a marked increase compared to 60% in HF urine.
conclusionThe 16S rDNA sequence data demonstrates a shift in the composition of the bacterial community in IC urine. The reduced microbial diversity and richness is accompanied by a higher abundance of the bacterial genus Lactobacillus, compared to HF urine. This study demonstrates that high throughput sequencing analysis of urine microbiota in IC patients is a powerful tool towards a better understanding of this enigmatic disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.