ArticleJournal of the American Chemical Society2012
Organic radical contrast agents for magnetic resonance imaging.
Article in Journal of the American Chemical Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 49 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed.
- Designing Water-Soluble Macromolecules for Biomedical Use: PEG Chains versus Amino AcidsA Case Study in MRI Contrast Agents.ACS polymers Au · 2026Article
- Nitroxide-Based Contrast Agents for MRI Cancer Diagnostics: Progress, Limitations, and Perspectives.Molecules (Basel, Switzerland) · 2026Review
- HACS omega · 2026Article
- Towards Metabolic Organic Radical Contrast Agents (mORCAs) for Magnetic Resonance Imaging.Molecules (Basel, Switzerland) · 2025Article
- Water-Soluble Bimodal Magnetic-Fluorescent Radical Dendrimers as Potential MRI-FI Imaging Probes.ACS applied materials & interfaces · 2024Article
- Contrast Agents Based on Human Serum Albumin and Nitroxides forInternational journal of molecular sciences · 2024Article
- Hydrogen Peroxide-Triggered Disassembly of Boronic Ester-Cross-Linked Brush-Arm Star Polymers.ACS macro letters · 2023Article
- Direct mapping of kidney function by DCE-MRI urography using a tetrazinanone organic radical contrast agent.Nature communications · 2023Article
- Long-Term Degradation Mechanisms in Application-Implemented Radical Thin Films.ACS applied materials & interfaces · 2023Article
- Novel nitroxide-bile acid conjugates inform substrate requirements for human bile acid transporters.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2023Article
- High-SpinJournal of the American Chemical Society · 2022Article
- Metal-Free Radical Dendrimers as MRI Contrast Agents for Glioblastoma Diagnosis:Biomacromolecules · 2022Article
- Organic radical materials in biomedical applications: State of the art and perspectives.Exploration (Beijing, China) · 2022Article
- Tethered Blatter Radical for Molecular Grafting: Synthesis of 6-Hydroxyhexyloxy, Hydroxymethyl, and Bis(hydroxymethyl) Derivatives and Their Functionalization.Molecules (Basel, Switzerland) · 2022Article
- Bis-Spiro-Oxetane and Bis-Spiro-Tetrahydrofuran Pyrroline Nitroxide Radicals: Synthesis and Electron Spin Relaxation Studies.The Journal of organic chemistry · 2021Article
- A nitroxides-based macromolecular MRI contrast agent with an extraordinary longitudinal relaxivity for tumor imaging via clinical T1WI SE sequence.Journal of nanobiotechnology · 2021Article
- Amphiphilic branched polymer-nitroxides conjugate as a nanoscale agent for potential magnetic resonance imaging of multiple objects in vivo.Journal of nanobiotechnology · 2021Article
- Interaction of Luminescent Defects in Carbon Nanotubes with Covalently Attached Stable Organic Radicals.ACS nano · 2021Article
- Multimodal Functional Imaging for Cancer/Tumor Microenvironments Based on MRI, EPRI, and PET.Molecules (Basel, Switzerland) · 2021Review
- Rational Design of All-Organic Nanoplatform for Highly Efficient MR/NIR-II Imaging-Guided Cancer Phototheranostics.Small (Weinheim an der Bergstrasse, Germany) · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors.
Funding
Abstract
We report a molecular design that provides an intravenously injectable organic radical contrast agent (ORCA) for which the molecular (1)H water relaxivity (r(1)) is ca. 5 mM(-1) s(-1). The ORCA is based on spirocyclohexyl nitroxide radicals and poly(ethylene glycol) chains conjugated to a fourth-generation polypropylenimine dendrimer scaffold. The metal-free ORCA has a long shelf life and provides selectively enhanced magnetic resonance imaging in mice for over 1 h.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.