Evidence map›Paper›PMID 22974174›Full record

SynthesisInfluenza and other respiratory viruses2013

A meta-analysis of intradermal versus intramuscular influenza vaccines: immunogenicity and adverse events.

Fawziah Marra, Flora Young, Kathryn Richardson, Carlo A Marra

Open access · greenAbstract readComparative StudyMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Influenza and other respiratory viruses, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 6 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 6 syntheses or guidelines pooled it, 57 citations in OpenAlex.

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  17. Challenges in the Vaccination of the Elderly and Strategies for Improvement.Pathophysiology : the official journal of the International Society for Pathophysiology · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Fawziah MarraFaculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada.
Flora Young
Kathryn Richardson
Carlo A Marra
University of British Columbia · CAFraser Health · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine immunogenicity and safety of intradermal (ID) influenza vaccines compared with intramuscular (IM) administration and effect of dose and age.

designMeta-anlysis.

settingSystematic review and meta-analysis of randomized controlled trials on influenza vaccines. SAMPLE: Randomized, controlled trials comparing ID seasonal split-virus influenza vaccines with 15 μg IM control in subjects 18 years of age or older and assessed antibody response at 21-28 days post-vaccination were considered for inclusion.

resultsA total of 13 trials were included. The pooled immunogenicity outcomes did not differ significantly between the IM and ID vaccine groups for the H1N1 (ratio of GMTR: 0·92, 95% confidence interval 0·77-1·09; seroconversion: 0·94, 0·86-1·02; seroprotection: 0·97, 0·94-1·00) and B strains (GMTR: 0·93, 0·80-1·08; seroconversion: 0·91, 0·80-1·04; seroprotection: 0·97, 0·91-1·03). For the H3N2 strain, there was no significant difference in GMTR (0·97, 0·80-1·18); however, there was a lower pooled seroconversion (0·89, 0·80-0·99) and seroprotection rate (0·98, 0·96-0·99) for ID recipients. There was a statistically significant association between increasing doses of the ID vaccination with increasing immunogenicity response (P = 0·01). There were no differences in adverse event rates within 3 days post-vaccination for ID versus IM. But for adverse events occurring 7 days post-vaccination, ID vaccination was associated with a greater incidence of local events but not systemic events.

conclusionsThere was no significant difference in immunologic response when comparing ID with IM administration of the influenza vaccination in the overall population, but higher doses of ID vaccine in the older adult population produced a better response.

Indexed as

AdolescentAdultAgedAged, 80 and overDrug-Related Side Effects and Adverse ReactionsFemaleHumansInfluenza VaccinesInjections, IntradermalInjections, IntramuscularMaleMiddle AgedRandomized Controlled Trials as TopicYoung AdultInfluenza Vaccines

Identifiers

PMID22974174
PMCPMC5781005
OpenAlexW2116431104

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.