ArticleDiagnostic pathology2012
Expression of c-Jun, p73, Casp9, and N-ras in thymic epithelial tumors: relationship with the current WHO classification systems.
Article in Diagnostic pathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Relationship of possible biomarkers with malignancy of thymic tumors: a meta-analysis.BMC cancer · 2020Pooled it
- Review
- TP73 is a credible biomarker for predicting clinical progression and prognosis in cervical cancer patients.Bioscience reports · 2019Article
- Wnt4 overexpression promotes thymoma development through a JNK-mediated planar cell polarity-like pathway.Oncology letters · 2018Article
- Chromosomal Alterations and Gene Expression Changes Associated with the Progression of Leukoplakia to Advanced Gingivobuccal Cancer.Translational oncology · 2017Article
- Retraction note: Cervical type AB thymoma (mixed) tumour diagnosis in a mynah as a model to study human: clinicohistological, immunohistochemical and cytohistopathological study.Diagnostic pathology · 2016Article
- Expression of cell cycle and apoptosis regulators in thymus and thymic epithelial tumors.Clinical and experimental medicine · 2016Review
- Immunohistological analysis of the jun family and the signal transducers and activators of transcription in thymus.Anatomy research international · 2015Article
- Cell Pluripotency Levels Associated with Imprinted Genes in Human.Computational and mathematical methods in medicine · 2015Article
- KRAS, EGFR, PDGFR-α, KIT and COX-2 status in carcinoma showing thymus-like elements (CASTLE).Diagnostic pathology · 2014Article
- Pathway landscapes and epigenetic regulation in breast cancer and melanoma cell lines.Theoretical biology & medical modelling · 2014Article
- Unusual combined thymic mucoepidermoid carcinoma and thymoma: a case report and review of literature.Diagnostic pathology · 2014Review
- Lipofibroadenoma of the thymus: a case report.Diagnostic pathology · 2013Article
- Thyroid nodule as a first manifestation of Hodgkin lymphoma-report of two cases and literature review.Diagnostic pathology · 2013Review
- Cervical type AB thymoma (Mixed) tumour diagnosis in a mynah as a model to study human: clinicohistological, immunohistochemical and cytohistopathological study.Diagnostic pathology · 2013Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo evaluate the expression and differential significance of c-Jun, p73, Casp-9 and N-ras in thymic epithelial tumors (TETs) with the aim to provide useful information for tumor biology and prospective therapy.
methodsIn this study, we analyzed the expression of four chromosome 1-related genes, namely c-Jun, p73, Casp-9 and N-ras, in 60 cases of thymic epithelial tumors. The tumors included 52 thymomas and 8 thymic carcinomas which were categorized according to the current WHO classification systems.
resultsCompared with the normal thymus tissue, all thymic epithelial tumors demonstrated higher expression of c-Jun and p73. The expression of c-Jun and p73 in type B2, B3 thymoma and thymic carcinomas was similar, and significantly higher than that in all other subtypes of thymomas. Unlike type A thymoma, the expression of Casp-9 was relatively lower in type B thymoma and thymic carcinomas. With respect to the clinical staging systems, c-Jun was more expressed in progressive tumors harboring higher stages. In contrast to c-Jun, p73 and Casp-9, there was no significant aberration with N-ras expression irrespective of either tissue or tumor types.
conclusionsThe overexpression of c-Jun, p73 and Casp-9 in thymic epithelial tumors is closely related with the pathogenesis and biological behavior of the neoplasms. These candidate biomarkers provided useful information for prospective personalized therapy in the clinical management. VIRTUAL SLIDES: http://www.diagnosticpathology.diagnomx.eu/vs/1521774814749726.
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