ArticleASN neuro2012
Nanoparticle targeting to neurons in a rat hippocampal slice culture model.
Article in ASN neuro, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Nanoparticle-based optical interfaces for retinal neuromodulation: a review.Frontiers in cellular neuroscience · 2024Review
- Upconverting Nanoparticles as a New Bio-Imaging Strategy-Investigating Intracellular Trafficking of Endogenous Processes in Neural Tissue.International journal of molecular sciences · 2023Article
- Biological Interfaces, Modulation, and Sensing with Inorganic Nano-Bioelectronic Materials.Small methods · 2020Article
- Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities.Nanomaterials (Basel, Switzerland) · 2020Review
- Leveraging the interplay of nanotechnology and neuroscience: Designing new avenues for treating central nervous system disorders.Advanced drug delivery reviews · 2019Review
- Tau antibody chimerization alters its charge and binding, thereby reducing its cellular uptake and efficacy.EBioMedicine · 2019Article
- Neurotoxicity, behavioral changes and gene-expression profile of mice exposed to SnSToxicology research · 2018Article
- Efficient Assembly of Quantum Dots with Homogenous Glycans Derived from Natural N-Linked Glycoproteins.Bioconjugate chemistry · 2018Article
- Evaluating the potential of using quantum dots for monitoring electrical signals in neurons.Nature nanotechnology · 2018Review
- Nanotechnology for Neuroscience: Promising Approaches for Diagnostics, Therapeutics and Brain Activity Mapping.Advanced functional materials · 2017Article
- Selective Targeting of Neurons with Inorganic Nanoparticles: Revealing the Crucial Role of Nanoparticle Surface Charge.ACS nano · 2017Article
- Quantum Dot-Peptide-Fullerene Bioconjugates for Visualization of in Vitro and in Vivo Cellular Membrane Potential.ACS nano · 2017Article
- Quantum dot-mediated delivery of siRNA to inhibit sphingomyelinase activities in brain-derived cells.Journal of neurochemistry · 2016Article
- Quantum dots and potential therapy for Krabbe's disease.Journal of neuroscience research · 2016Review
- Cytotoxicity Study on Luminescent Nanocrystals Containing Phospholipid Micelles in Primary Cultures of Rat Astrocytes.PloS one · 2016Article
- Measuring brain lipids.Biochimica et biophysica acta · 2015Review
- Delivery and tracking of quantum dot peptide bioconjugates in an intact developing avian brain.ACS chemical neuroscience · 2015Article
- Peptides and proteins used to enhance gold nanoparticle delivery to the brain: preclinical approaches.International journal of nanomedicine · 2015Review
- Selecting improved peptidyl motifs for cytosolic delivery of disparate protein and nanoparticle materials.ACS nano · 2013Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
We have previously shown that CdSe/ZnS core/shell luminescent semiconductor nanocrystals or QDs (quantum dots) coated with PEG [poly(ethylene glycol)]-appended DHLA (dihydrolipoic acid) can bind AcWG(Pal)VKIKKP(9)GGH(6) (Palm1) through the histidine residues. The coating on the QD provides colloidal stability and this peptide complex uniquely allows the QDs to be taken up by cultured cells and readily exit the endosome into the soma. We now show that use of a polyampholyte coating [in which the neutral PEG is replaced by the negatively heterocharged CL4 (compact ligand)], results in the specific targeting of the palmitoylated peptide to neurons in mature rat hippocampal slice cultures. There was no noticeable uptake by astrocytes, oligodendrocytes or microglia (identified by immunocytochemistry), demonstrating neuronal specificity to the overall negatively charged CL4 coating. In addition, EM (electron microscopy) images confirm the endosomal egress ability of the Palm1 peptide by showing a much more disperse cytosolic distribution of the CL4 QDs conjugated to Palm1 compared with CL4 QDs alone. This suggests a novel and robust way of delivering neurotherapeutics to neurons.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.