Evidence map›Paper›PMID 22973853›Full record

ReviewCurrent HIV research2012

Substance abuse, HIV-1 and hepatitis.

Nirzari Parikh, Michael R Nonnemacher, Vanessa Pirrone, Timothy Block, Anand Mehta, Brian Wigdahl

Open access · bronzeAbstract readReview
In one paragraph

Review in Current HIV research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Article
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  8. Article
  9. Article
  10. Elevated Neutrophil to Lymphocyte Ratio in Older Adults with Cocaine Use Disorder as a Marker of Chronic Inflammation.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2020
    Article
  11. Discovering major opioid-related research themes over time: A text mining technique.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2019
    Article
  12. Article
  13. Article
  14. Article
  15. Article
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  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Nirzari ParikhDepartment of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19102, USA.
Michael R Nonnemacher
Vanessa Pirrone
Timothy Block
Anand Mehta
Brian Wigdahl
Institute for Molecular Medicine · USHepatitis B Foundation · USDrexel University · US

Funding

High Specificity HIV-1 Markers Predictive of Neuro-AIDSR01DA019807 · NIDA · DREXEL UNIVERSITY · PI WIGDAHL, BRIAN · 2004 to 2014
$5.1M
Predicting HCC through GlycomicsR01CA120206 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MEHTA, ANAND S. · 2006 to 2016
$4.3M
NEUROLOGICAL &LYMPHOID FACTORS IN HIV1 LTR ACTIVATIONR01NS032092 · NINDS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI WIGDAHL, BRIAN · 1993 to 2011
$3.9M
Liver Cancer and the Role of Protein Hyper-FucosylationR01CA136607 · NCI · DREXEL UNIVERSITY · PI BLOCK, TIMOTHY M · 2009 to 2013
$2.0M
Co-evolution of HIV-1 Regulators in CNS DiseaseR01NS046263 · NINDS · DREXEL UNIVERSITY · PI WIGDAHL, BRIAN · 2004 to 2009
$1.8M
NCI NIH HHS R01 CA120206NCI NIH HHS R01 CA136607NIDA NIH HHS DA19807NIDA NIH HHS R01 DA019807NINDS NIH HHS NS32092NINDS NIH HHS NS46263NINDS NIH HHS R01 NS032092NINDS NIH HHS R01 NS046263
6 · The paper itself

Abstract

During the course of human immunodeficiency virus type 1 (HIV-1) disease, the virus has been shown to effectively escape the immune response with the subsequent establishment of latent viral reservoirs in specific cell populations within the peripheral blood (PB) and associated lymphoid tissues, bone marrow (BM), brain, and potentially other end organs. HIV-1, along with hepatitis B and C viruses (HBV and HCV), are known to share similar routes of transmission, including intravenous drug use, blood transfusions, sexual intercourse, and perinatal exposure. Substance abuse, including the use of opioids and cocaine, is a significant risk factor for exposure to HIV-1 and the development of acquired immune deficiency syndrome, as well as HBV and HCV exposure, infection, and disease. Thus, coinfection with HIV-1 and HBV or HCV is common and may be impacted by chronic substance abuse during the course of disease. HIV- 1 impacts the natural course of HBV and HCV infection by accelerating the progression of HBV/HCV-associated liver disease toward end-stage cirrhosis and quantitative depletion of the CD4+ T-cell compartment. HBV or HCV coinfection with HIV-1 is also associated with increased mortality when compared to either infection alone. This review focuses on the impact of substance abuse and coinfection with HBV and HCV in the PB, BM, and brain on the HIV-1 pathogenic process as it relates to viral pathogenesis, disease progression, and the associated immune response during the course of this complex interplay. The impact of HIV-1 and substance abuse on hepatitis virus-induced disease is also a focal point.

Indexed as

Acquired Immunodeficiency SyndromeBloodBone MarrowBrainCoinfectionDisease ProgressionFemaleHepatitis BHepatitis CHIV-1HIV SeropositivityHumansMaleSubstance Abuse, IntravenousUnited States

Identifiers

PMID22973853
PMCPMC3708479
OpenAlexW109222942

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.