ArticleFrontiers in oncology2012
Do circulating tumor cells play a role in coagulation and thrombosis?
Article in Frontiers in oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 29 citations in OpenAlex.
- Review
- Circulating tumor nucleic acids: biology, release mechanisms, and clinical relevance.Molecular cancer · 2023Review
- Circulating ensembles of tumor-associated cells: A redoubtable new systemic hallmark of cancer.International journal of cancer · 2020Observational
- Analysis of platelet parameters and activation markers in hematologic metastases of lung cancer.Chinese medical journal · 2019Article
- Noninvasive label-free detection of circulating white and red blood clots in deep vessels with a focused photoacoustic probe.Biomedical optics express · 2018Article
- Cancer-associated thrombosis: The search for the holy grail continues.Research and practice in thrombosis and haemostasis · 2018Review
- The coagulome and the oncomir: impact of cancer-associated haemostatic dysregulation on the risk of metastasis.Clinical & experimental metastasis · 2018Review
- Pseudocellulitis Need Not be Benign: Three Cases of Superficial Migratory Thrombophlebitis with "Negative" Venous Duplex Ultrasonography.The Journal of clinical and aesthetic dermatology · 2017Article
- A circulating tumor cell cluster-based model for tumor metastasis (Hypothesis).Oncology letters · 2016Article
- Circulating Tumor Cells: When a Solid Tumor Meets a Fluid Microenvironment.Advances in experimental medicine and biology · 2016Article
- Article
- The thrombotic potential of circulating tumor microemboli: computational modeling of circulating tumor cell-induced coagulation.American journal of physiology. Cell physiology · 2015Article
- Early venous thromboembolic events are associated with worse prognosis in patients with lung cancer.Lung cancer (Amsterdam, Netherlands) · 2014Article
- Metastasis review: from bench to bedside.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Review
- Physical biology in cancer. 2. The physical biology of circulating tumor cells.American journal of physiology. Cell physiology · 2014Review
- Interrelationships of circulating tumor cells with metastasis and thrombosis: role of microRNAs.Current pharmaceutical design · 2014Review
- Activation of blood coagulation in cancer: implications for tumour progression.Bioscience reports · 2013Review
- Physiological levels of blood coagulation factors IX and X control coagulation kinetics in an in vitro model of circulating tissue factor.Physical biology · 2013Article
- Perspective: Flicking with flow: Can microfluidics revolutionize the cancer research?Biomicrofluidics · 2013Article
- Microfluidics and coagulation biology.Annual review of biomedical engineering · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Cancer induces a hypercoagulable state, and patients with cancer who suffer a thrombotic event have a worse prognosis than those who do not. Recurrent pathologic thrombi in patients with cancer are clinically managed with anticoagulant medications; however, anticoagulant prophylaxis is not routinely prescribed owing to a complex variety of patient and diagnosis related factors. Early identification of patients at risk for cancer-associated thrombosis would allow for personalization of anticoagulant prophylaxis and likely reduce morbidity and mortality for many cancers. The environment in which a thrombosis develops in a patient with cancer is complex and unique from patients without cancer, which creates therapeutic challenges but may also provide targets for the development of clinical assays in this context. Circulating tumor cells (CTCs) may play a role in the association between cancer and thrombosis. Cancer metastasis, the leading cause of cancer-related deaths, is facilitated by the hematogenous spread of CTCs, and CTCs accompany metastatic disease across all major types of carcinomas. The role of CTCs in the pathogenesis of thrombosis has not been studied due to the previous difficulty in identifying these rare cells, but the interaction between these circulating cells and the coagulation system is an area of study that demands attention. The development of CTC detection platforms presents a new tool by which to characterize the role for CTCs in cancer-related hypercoagulability. In addition, this area of study presents a new avenue for assessing the risk of cancer-associated thrombosis and represents a potential tool for predicting which patients may benefit from anticoagulant prophylaxis. In this review, we will discuss the evidence in support of CTC induced hypercoagulability, and highlight areas where CTC-detection platforms may provide prognostic insight into the risk of developing thrombosis for patients with cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.