Evidence map›Paper›PMID 22973536›Full record

ArticleG3 (Bethesda, Md.)2012

oPOSSUM-3: advanced analysis of regulatory motif over-representation across genes or ChIP-Seq datasets.

Andrew T Kwon, David J Arenillas, Rebecca Worsley Hunt, Wyeth W Wasserman

Abstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 201 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
201citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

201 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  8. Enrichment ofInternational journal of molecular sciences · 2024
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141 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Andrew T KwonCentre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, V5Z 4H4, Canada.
David J Arenillas
Rebecca Worsley Hunt
Wyeth W Wasserman

Funding

Computational Resources for the Compilation and Distribution of Transcription FacR01GM084875 · NIGMS · UNIVERSITY OF BRITISH COLUMBIA · PI WASSERMAN, WYETH W · 2010 to 2012
$1.0M
CIHRNIGMS NIH HHS 1R01GM084875NIGMS NIH HHS R01 GM084875
6 · The paper itself

Abstract

oPOSSUM-3 is a web-accessible software system for identification of over-represented transcription factor binding sites (TFBS) and TFBS families in either DNA sequences of co-expressed genes or sequences generated from high-throughput methods, such as ChIP-Seq. Validation of the system with known sets of co-regulated genes and published ChIP-Seq data demonstrates the capacity for oPOSSUM-3 to identify mediating transcription factors (TF) for co-regulated genes or co-recovered sequences. oPOSSUM-3 is available at http://opossum.cisreg.ca.

Indexed as

Nucleotide MotifsRegulatory Sequences, Nucleic AcidSoftwareAnimalsBase CompositionBinding SitesChromatin ImmunoprecipitationCiliaComputational BiologyHigh-Throughput Nucleotide SequencingHumansInternetMuscle, SkeletalNematodaTranscription FactorsTranscription FactorsChIP-Seqgene regulationtranscriptiontranscription factor binding sites (TFBS)

Identifiers

PMID22973536
PMCPMC3429929

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.