ArticleInternational journal of nephrology2012
Variation in APOL1 Contributes to Ancestry-Level Differences in HDLc-Kidney Function Association.
Article in International journal of nephrology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 29 citations in OpenAlex.
- Examination of Potential Modifiers of the Association of APOL1 Alleles with CKD Progression.Clinical journal of the American Society of Nephrology : CJASN · 2015Trial
- Estimated glucose disposal rate mediates the association between Life's Crucial 9 and congestive heart failure: a population-based study.Frontiers in endocrinology · 2025Article
- Ecstasy metabolites and monoamine neurotransmitters upshift the NaArchives of toxicology · 2022Article
- Variant APOL1 protein in plasma associates with larger particles in humans and mouse models of kidney injury.PloS one · 2022Article
- Interethnic Differences in Serum Lipids and Implications for Cardiometabolic Disease Risk in African Ancestry Populations.Global heart · 2017Review
- Effect of high density lipoprotein cholesterol on the relationship of serum iron and hemoglobin with kidney function in diabetes.Journal of diabetes and its complications · 2017Article
- Apolipoprotein L1 and Kidney Disease in African Americans.Trends in endocrinology and metabolism: TEM · 2016Review
- APOL1 Genotype, Kidney and Cardiovascular Disease, and Death in Older Adults.Arteriosclerosis, thrombosis, and vascular biology · 2016Article
- APOL1 genetic variants, chronic kidney diseases and hypertension in mixed ancestry South Africans.BMC genetics · 2015Article
- APOL1 G1 genotype modifies the association between HDLC and kidney function in African Americans.BMC genomics · 2015Article
- African origins and chronic kidney disease susceptibility in the human immunodeficiency virus era.World journal of nephrology · 2015Review
- APOL1 Kidney Disease Risk Variants: An Evolving Landscape.Seminars in nephrology · 2015Review
- Insulin signaling: implications for podocyte biology in diabetic kidney disease.Current opinion in nephrology and hypertension · 2015Article
- Lipid biology of the podocyte--new perspectives offer new opportunities.Nature reviews. Nephrology · 2014Review
- Research capacity. Enabling the genomic revolution in Africa.Science (New York, N.Y.) · 2014Article
- Evolution of the primate trypanolytic factor APOL1.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- The biology of APOL1 with insights into the association between APOL1 variants and chronic kidney disease.Clinical and experimental nephrology · 2014Review
- Serum HDL-C level of Iranian adults: results from sixth national Surveillance of Risk Factors of Non-Communicable Disease.Journal of diabetes and metabolic disorders · 2014Article
- APOL1 and nephropathy progression in populations of African ancestry.Seminars in nephrology · 2013Review
- Interethnic Variation in Lipid Profiles: Implications for Underidentification of African-Americans at risk for Metabolic Disorders.Expert review of endocrinology & metabolism · 2012Article
Corrections and comments
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Authors and funding
22 authors at 8 institutions in 4 countries.
Funding
Abstract
Low levels of high-density cholesterol (HDLc) accompany chronic kidney disease, but the association between HDLc and the estimated glomerular filtration rate (eGFR) in the general population is unclear. We investigated the HDLc-eGFR association in nondiabetic Han Chinese (HC, n = 1100), West Africans (WA, n = 1497), and African Americans (AA, n = 1539). There were significant differences by ancestry: HDLc was positively associated with eGFR in HC (β = 0.13, P < 0.0001), but negatively associated among African ancestry populations (WA: -0.19, P < 0.0001; AA: -0.09, P = 0.02). These differences were also seen in nationally-representative NHANES data (among European Americans: 0.09, P = 0.005; among African Americans -0.14, P = 0.03). To further explore the findings in African ancestry populations, we investigated the role of an African ancestry-specific nephropathy risk variant, rs73885319, in the gene encoding HDL-associated APOL1. Among AA, an inverse HDLc-eGFR association was observed only with the risk genotype (-0.38 versus 0.001; P = 0.03). This interaction was not seen in WA. In summary, counter to expectation, an inverse HDLc-eGFR association was observed among those of African ancestry. Given the APOL1 × HDLc interaction among AA, genetic factors may contribute to this paradoxical association. Notably, these findings suggest that the unexplained mechanism by which APOL1 affects kidney-disease risk may involve HDLc.
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Registered trials
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