ArticleMediterranean journal of hematology and infectious diseases2012
Platelet Count Response to Helicobacter pylori Eradication in Iranian Patients with Idiopathic Thrombocytopenic Purpura.
Article in Mediterranean journal of hematology and infectious diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- A Comprehensive Survey of the Relationship betweenArchives of Iranian medicine · 2022Pooled it
- Investigating the link betweenAnnals of medicine and surgery (2012) · 2026Article
- Evaluating the relationship betweenAnnals of medicine and surgery (2012) · 2021Article
- Article
- Effect ofBlood research · 2021Article
- Review
- Therapeutic effects of rituximab combined with cyclophosphamide on refractory idiopathic thrombocytopenic purpura.Experimental and therapeutic medicine · 2019Article
- Helicobacter pylori Eradication in Patients with Immune Thrombocytopenic Purpura: A Review and the Role of Biogeography.Helicobacter · 2015Review
- Hematologic manifestations of Helicobacter pylori infection.World journal of gastroenterology · 2014Review
- From prednisone to pylori: a case of Helicobacter pylori-induced chronic immune thrombocytopenia.BMJ case reports · 2014Article
- Helicobacter pylori infection and diabetes: is it a myth or fact?World journal of gastroenterology · 2014Review
- Helicobacter pylori infection and insulin resistance in diabetic and nondiabetic population.TheScientificWorldJournal · 2014Article
- Poor platelet Count Response to Helicobacter Pylori Eradication in Patients with Severe Idiopathic Thrombocytopenic Purpura.International journal of hematology-oncology and stem cell research · 2013Article
- Helicobacter pylori infection prevalence: Is it different in diabetics and nondiabetics?Indian journal of endocrinology and metabolismArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Idiopathic thrombocytopenic purpura (ITP) is an autoimmune hematological disorder characterized by auto antibody-mediated platelet destruction. Although the main cause of ITP remains unclear, but its relationship with some infection was demonstrated. In recent years, many studies have demonstrated improvement of platelet counts in ITP patients after treating Helicobacter pylori infection. The aim of this study was to investigate the effects of H. pylori eradication on platelet count response in Iranian ITP patients.A total of 26 patients diagnosed with both ITP and H. pylori infection. ITP were diagnosed whose platelet counts were less than 100×10(3)/μL. These patients were tested for H. pylori infection by Urea Breath Test and serum H. pylori antibody. All patients received triple therapy for 7 or 14 days to eradicate H. pylori infection. These patients followed for six months.Prevalence of H. pylori was 67.3%. H. pylori eradication achieved in 89.5% (26/29). Of the 26 patients, 15 (57.7%) exhibited a complete response (CR) and 11 (42.3%) were unresponsive. We did not find partial responders. There was a significant difference in the baseline platelet count of responders and non-responders patients (p<0.001). All responders had platelet count ≥50×10(3)/μL and all non-responders had platelet count <50×10(3)/μL.Results of this study revealed that eradication therapy of H. pylori infection can improve platelet counts in ITP patients especially with mild thrombocytopenia and support routine detection and treatment of H. pylori infection in ITP patients in populations with a high prevalence of this infection.
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Registered trials
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