ArticleFrontiers in immunology2012
Defense peptides secreted by helminth pathogens: antimicrobial and/or immunomodulator molecules?
Article in Frontiers in immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Immunomodulatory effects of nematode-microbiota interactions in cancer therapy.Frontiers in immunology · 2026Review
- Association of Antibodies to Helminth Defense Molecule 1 With Inflammation, Organomegaly, and Decreased Nutritional Status in Schistosomiasis Japonica.The Journal of infectious diseases · 2024Article
- Link between bacterial communities and contrasted loads in ectoparasitic monogeneans from the external mucus of two wild sparid species (Teleostei).Animal microbiome · 2024Article
- Parasite-gut microbiota associations in wild wood mice (Frontiers in microbiology · 2024Article
- Recent Discoveries on Marine Organism Immunomodulatory Activities.Marine drugs · 2022Review
- Diversity and structure of sparids external microbiota (Teleostei) and its link with monogenean ectoparasites.Animal microbiome · 2022Article
- Functional Ultrastructure of the Excretory Gland Cell in Zoonotic Anisakids (Anisakidae, Nematoda).Cells · 2019Article
- Worms: Pernicious parasites or allies against allergies?Parasite immunology · 2019Review
- Sequential Changes in the Host Gut Microbiota During Infection With the Intestinal Parasitic NematodeFrontiers in cellular and infection microbiology · 2019Article
- The impact of a helminth-modified microbiome on host immunity.Mucosal immunology · 2018Review
- Parasite-Microbiota Interactions With the Vertebrate Gut: Synthesis Through an Ecological Lens.Frontiers in microbiology · 2018Review
- Insight into the molecular basis of Schistosoma haematobium-induced bladder cancer through urine proteomics.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Cysteine protease is a major component in the excretory/secretory products of Euclinostomum heterostomum (Digenea: Clinostomidae).Parasitology research · 2014Article
- pH-dependent solution structure and activity of a reduced form of the host-defense peptide myticin C (Myt C) from the mussel Mytilus galloprovincialis.Marine drugs · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Host defense peptides (HDPs) are an evolutionarily conserved component of the innate immune response found in all living species. They possess antimicrobial activities against a broad range of organisms including bacteria, fungi, eukaryotic parasites, and viruses. HDPs also have the ability to enhance immune responses by acting as immunomodulators. We discovered a new family of HDPs derived from pathogenic helminth (worms) that cause enormous disease in animals and humans worldwide. The discovery of these peptides was based on their similar biochemical and functional characteristics to the human defense peptide LL-37. We propose that these new peptides modulate the immune response via molecular mimicry of mammalian HDPs thus providing a mechanism behind the anti-inflammatory properties of helminth infections.
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Registered trials
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