ArticleFrontiers in behavioral neuroscience2012
Blocking muscarinic receptors in the olfactory bulb impairs performance on an olfactory short-term memory task.
Article in Frontiers in behavioral neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Olfactory dysfunction and its related molecular mechanisms in Parkinson's disease.Neural regeneration research · 2024Review
- Article
- Molecular and Genetic Factors Involved in Olfactory and Gustatory Deficits and Associations with Microbiota in Parkinson's Disease.International journal of molecular sciences · 2021Review
- Experience enhances certainty about olfactory stimuli under bulbar cholinergic control.Learning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- Aversive learning-induced plasticity throughout the adult mammalian olfactory system: insights across development.Journal of bioenergetics and biomembranes · 2019Review
- Olfactory Bulb Muscarinic Acetylcholine Type 1 Receptors Are Required for Acquisition of Olfactory Fear Learning.Frontiers in behavioral neuroscience · 2019Article
- Olfactory Dysfunction in Neurodegenerative Diseases.Current allergy and asthma reports · 2018Review
- Mice Lacking M1 and M3 Muscarinic Acetylcholine Receptors Have Impaired Odor Discrimination and Learning.Frontiers in synaptic neuroscience · 2017Article
- Increased olfactory bulb acetylcholine bi-directionally modulates glomerular odor sensitivity.Scientific reports · 2016Article
- Basal forebrain dynamics during nonassociative and associative olfactory learning.Journal of neurophysiology · 2016Article
- Functional differentiation of cholinergic and noradrenergic modulation in a biophysical model of olfactory bulb granule cells.Journal of neurophysiology · 2015Article
- Distinct roles of bulbar muscarinic and nicotinic receptors in olfactory discrimination learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Properties and mechanisms of olfactory learning and memory.Frontiers in behavioral neuroscience · 2014Review
- Paying attention to smell: cholinergic signaling in the olfactory bulb.Frontiers in synaptic neuroscience · 2014Review
- Reorganization of neuronal circuits of the central olfactory system during postprandial sleep.Frontiers in neural circuits · 2013Review
- Roles of GSK3β in odor habituation and spontaneous neural activity of the mouse olfactory bulb.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Cholinergic inputs to cortical processing networks have long been associated with attentional and top-down processing. Experimental and theoretical studies suggest that cholinergic inputs to the main olfactory bulb (OB) can modulate both neural and behavioral odor discrimination. Previous experiments from our laboratory and others demonstrate that blockade of nicotinic receptors directly impairs olfactory discrimination, whereas blockade of muscarinic receptors only measurably impairs olfactory perception when task demands are made more challenging, such as when very low-concentration odors are used or rats are required to maintain sensory memory over long durations. To further investigate the role of muscarinic signaling in the OB, we developed an olfactory delayed match-to-sample task using a digging-based behavioral paradigm. We find that rats are able to maintain robust short-term odor memory for 10-100 s. To investigate the role of muscarinic signaling in task performance, we bilaterally infused scopolamine into the OB. We find that high dosages of scopolamine (38 mM) impair performance on the task across all delays tested, including the baseline condition with no delay, whereas lower dosages (7.6 mM and 22.8 mM) had no measureable effects. These results indicate that general execution of the match-to-sample task, even with no delay, is at least partially dependent on muscarinic signaling in the OB.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.