ArticleFrontiers in neuroscience2012
The road not taken: neural correlates of decision making in orbitofrontal cortex.
Article in Frontiers in neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Structural and functional organization of the midline and intralaminar nuclei of the thalamus.Frontiers in behavioral neuroscience · 2022Pooled it
- Online evaluation of novel choices by simultaneous representation of multiple memories.Nature neuroscience · 2013Trial
- Article
- The Optically Guided and Pre-assembled Implantation Cranial Window Reveals Cortical Spatial Representations during Navigation.Research (Washington, D.C.) · 2026Article
- The orbitofrontal cortex updates beliefs for state inference.bioRxiv : the preprint server for biology · 2025Article
- Choice Behaviors and Prefrontal-Hippocampal Coupling Are Disrupted in a Rat Model of Fetal Alcohol Spectrum Disorders.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Mental Time Travel: A Retrospective.Hippocampus · 2025Review
- Environmental complexity modulates information processing and the balance between decision-making systems.Neuron · 2024Article
- Deliberative Behaviors and Prefrontal-Hippocampal Coupling are Disrupted in a Rat Model of Fetal Alcohol Spectrum Disorders.bioRxiv : the preprint server for biology · 2024Article
- Organization of orbitofrontal-auditory pathways in the Mongolian gerbil.The Journal of comparative neurology · 2023Article
- Pausing and reorienting behaviors enhance the performance of a spatial working memory task.Behavioural brain research · 2023Article
- Distinct forms of regret linked to resilience versus susceptibility to stress are regulated by region-specific CREB function in mice.Science advances · 2022Article
- The ventral midline thalamus coordinates prefrontal-hippocampal neural synchrony during vicarious trial and error.Scientific reports · 2022Article
- Computational validity: using computation to translate behaviours across species.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Subpopulations of neurons in lOFC encode previous and current rewards at time of choice.eLife · 2021Article
- Spatial Representations in Rat Orbitofrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Formalizing planning and information search in naturalistic decision-making.Nature neuroscience · 2021Review
- Memory and decision making interact to shape the value of unchosen options.Nature communications · 2021Article
- Potential roles of the rodent medial prefrontal cortex in conflict resolution between multiple decision-making systems.International review of neurobiology · 2021Review
- Non-linear Functional Brain Co-activations in Short-Term Memory Distortion Tasks.Frontiers in neuroscience · 2021Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Empirical research links human orbitofrontal cortex (OFC) to the evaluation of outcomes during decision making and the representation of alternative (better) outcomes after failures. When faced with a difficult decision, rats sometimes pause and turn back-and-forth toward goals, until finally orienting toward the chosen direction. Neural representations of reward in rodent OFC increased immediately following each reorientation, implying a transient representation of the expected outcome following self-initiated decisions. Upon reaching reward locations and finding no reward (having made an error), OFC representations of reward decreased locally indicating a disappointment signal that then switched to represent the unrewarded, non-local, would-have-been rewarded site. These results illustrate that following a decision to act, neural ensembles in OFC represent reward, and upon the realization of an error, represent the reward that could have been.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.