ArticleOncoTargets and therapy2012
Expression of transient receptor potential channel 6 in cervical cancer.
Article in OncoTargets and therapy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- Transient Receptor Potential Canonical 6 (TRPC6) Channel in the Pathogenesis of Diseases: A Jack of Many Trades.Inflammation · 2023Review
- Pharmacological targeting transient receptor potential canonical channel 6 modulates biological behaviors for cervical cancer HeLa and SiHA cell.Cancer cell international · 2022Article
- Expression and localization of transient receptor potential channels in the bovine uterus epithelium throughout the estrous cycle.Molecular biology reports · 2019Article
- Combined detection of Twist1, Snail1 and squamous cell carcinoma antigen for the prognostic evaluation of invasion and metastasis in cervical squamous cell carcinoma.International journal of clinical oncology · 2018Article
- Inhibition of TRPC6 reduces non-small cell lung cancer cell proliferation and invasion.Oncotarget · 2017Article
- Analyzing large gene expression and methylation data profiles using StatBicRM: statistical biclustering-based rule mining.PloS one · 2015Article
- Lovastatin inhibits human B lymphoma cell proliferation by reducing intracellular ROS and TRPC6 expression.Biochimica et biophysica acta · 2014Article
- High expression of transient potential receptor C6 correlated with poor prognosis in patients with esophageal squamous cell carcinoma.Medical oncology (Northwood, London, England) · 2013Article
- TRPC6 is ubiquitously present in lymphatic tissues: A study using samples from body donors.Medicine internationalArticle
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent studies have reported that aberrant expression of transient receptor potential channel C6 (TRPC6) in a variety of human cancers is associated with aggressive behavior. However, the functional significance of TRPC6 in human cervical cancer is not known. This study was planned to detect whether TRPC6 is expressed in cervical cancer tissue and to evaluate the association between TPRC6 expression and clinicopathologic features.
methodsTissue samples were collected from the West China Second UNIV Hospital of Sichuan University. TRPC6 expression was detected by quantitative real-time reverse transcription polymerase chain reaction and Western blotting. TRPC6 expression was evaluated by immunohistochemistry analysis of 40 cervical cancer specimens, and correlations were sought between elevated expression of TRPC6 and clinicopathologic features.
resultsIncreased expression of TRPC6 was detected in 25 of the 40 cervical cancer samples. Positive cells found in cervical carcinomas were significantly increased in numbers compared with specimens without lymphovascular space invasion. Elevated expression of TRPC6 was neither related to International Federation of Gynecology and Obstetrics stage nor pelvic lymph metastases. Indeed, the clinicopathologic analysis indicated that overexpression of TRPC6 was significantly associated with lymphovascular space invasion.
conclusionThese results indicate that elevated expression of TRPC6 might be associated with an aggressive cervical cancer phenotype.
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