ReviewInternational journal of chronic obstructive pulmonary disease2012
Muscle function in COPD: a complex interplay.
Review in International journal of chronic obstructive pulmonary disease, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
66 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- The Impact of Different Mobile Health Technologies on Physical Activity of COPD Patients: A Systematic Review and Network Meta-Analysis.Journal of medical systems · 2025Pooled it
- Mobility impact and methods of diaphragm monitoring in patients with chronic obstructive pulmonary disease: a systematic review.Clinics (Sao Paulo, Brazil) · 2020Pooled it
- Neuromuscular electrical stimulation for muscle weakness in adults with advanced disease.The Cochrane database of systematic reviews · 2016Pooled it
- Effects of external diaphragm pacing combined with conventional rehabilitation therapies in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis.Therapeutic advances in respiratory diseasePooled it
- Effects of pulmonary-based Qigong exercise in stable patients with chronic obstructive pulmonary disease: a randomized controlled trial.BMC complementary medicine and therapies · 2023Trial
- Trial
- Effects of eccentric, concentric and eccentric/concentric training on muscle function and mass, functional performance, cardiometabolic health, quality of life and molecular adaptations of skeletal muscle in COPD patients: a multicentre randomised trial.BMC pulmonary medicine · 2022Trial
- Frailty transitions and associated clinical outcomes in patients with stable COPD: A longitudinal study.PloS one · 2020Trial
- Effects of neurally adjusted ventilatory assist on air distribution and dead space in patients with acute exacerbation of chronic obstructive pulmonary disease.Critical care (London, England) · 2017Trial
- Short-term inspiratory muscle training, aerobic exercise, and detraining in women with COPD: a randomized controlled trial.BMC sports science, medicine & rehabilitation · 2026Article
- The effect of pectoralis muscle area and nutritional index on the need for NIV treatment in COPD patients with acute respiratory failure.Irish journal of medical science · 2026Article
- Targeting dyspnoea through exercise intensity: insights from pulmonary rehabilitation and beyond, a narrative review.Frontiers in rehabilitation sciences · 2026Review
- Applying the COM-B Model to Understand Adherence to Tele-Exercise Prehabilitation Among Older Patients with Lung Cancer: A Qualitative Study.Patient preference and adherence · 2026Article
- Pectoral muscle area derived from chest computed tomography to identify quadriceps muscle weakness in COPD.ERJ open research · 2025Article
- Maximal Forced Inspiratory Flow Dynamics and Acute Exacerbation in Chronic Obstructive Pulmonary Disease Patients with Exacerbation History.Tuberculosis and respiratory diseases · 2025Article
- Identifying Metabolomic Biomarkers of Lung Function Decline in People with HIV.Journal of acquired immune deficiency syndromes (1999) · 2025Article
- The effects of sex hormones on BDNF secretion in airway smooth muscle of patients with obstructive pulmonary disease.Heliyon · 2025Review
- Effect of low-moderate intensity traditional Chinese exercises combined with acupuncture on patients with stable chronic obstructive pulmonary disease: study protocol for a randomized controlled trial.Frontiers in medicine · 2025Article
- Effect of Phytochemical-Rich Food Intake on Respiratory and Muscle Function in Middle-Aged Patients with COPD: A Cross-Sectional Study.Nutrients · 2024Article
- Enhanced diaphragm excursion and exercise tolerance in COPD patients through inspiratory muscle training after standardised pulmonary rehabilitation: randomised controlled trial.ERJ open research · 2024Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The skeletal muscles play an essential role in life, providing the mechanical basis for respiration and movement. Skeletal muscle dysfunction is prevalent in all stages of chronic obstructive pulmonary disease (COPD), and significantly influences symptoms, functional capacity, health related quality of life, health resource usage and even mortality. Furthermore, in contrast to the lungs, the skeletal muscles are potentially remedial with existing therapy, namely exercise-training. This review summarizes clinical and laboratory observations of the respiratory and peripheral skeletal muscles (in particular the diaphragm and quadriceps), and current understanding of the underlying etiological processes. As further progress is made in the elucidation of the molecular mechanisms of skeletal muscle dysfunction, new pharmacological therapies are likely to emerge to treat this important extra-pulmonary manifestation of COPD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.