ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Spatiotemporal reconfiguration of large-scale brain functional networks during propofol-induced loss of consciousness.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02253758 (Arousal Pathways and Emergence From Sedation), which is not on this map. Cited by 75 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Arousal Pathways and Emergence From Sedation
Who cites it
75 citing papers in PubMed, 1 synthesis or guideline pooled it, 146 citations in OpenAlex.
- Anesthetic effects of propofol in the healthy human brain: functional imaging evidence.Journal of anesthesia · 2015Pooled it
- Reorganisation of Brain Hubs across Altered States of Consciousness.Scientific reports · 2020Trial
- Trial
- Neurophysiological connectomic signatures of consciousness during propofol-induced general anesthesia.Cell reports. Medicine · 2026Article
- The association between motor coordination impairment and altered functional connectivity among autistic children.Frontiers in pediatrics · 2026Article
- Distinct effects of global signal regression on brain activity during propofol and sevoflurane anesthesia.Frontiers in neuroscience · 2025Article
- Neural Network Mechanisms Underlying General Anesthesia: Cortical and Subcortical Nuclei.Neuroscience bulletin · 2024Review
- The effects of propofol anaesthesia on molecular-enriched networks during resting-state and naturalistic listening.NeuroImage · 2023Article
- Frequency-specific brain network architecture in resting-state fMRI.Scientific reports · 2023Article
- Enhanced brain parcellation via abnormality inpainting for neuroimage-based consciousness evaluation of hydrocephalus patients by lumbar drainage.Brain informatics · 2023Article
- Beyond noise to function: reframing the global brain activity and its dynamic topography.Communications biology · 2022Review
- Arousal impacts distributed hubs modulating the integration of brain functional connectivity.NeuroImage · 2022Article
- Paradoxical markers of conscious levels: Effects of propofol on patients in disorders of consciousness.Frontiers in human neuroscience · 2022Article
- fMRI lag structure during waking up from early sleep stages.Cortex; a journal devoted to the study of the nervous system and behavior · 2021Article
- Article
- The ecological validity of MET was favourable in sitting implicit sequence learning consciousness by eyes closed and eyes open resting states fMRI.Scientific reports · 2021Article
- Brain network motifs are markers of loss and recovery of consciousness.Scientific reports · 2021Article
- No cognitive processing in the unconscious, anesthetic-like, state of sleep.The Journal of comparative neurology · 2021Review
- Distinct and Dissociable EEG Networks Are Associated With Recovery of Cognitive Function Following Anesthesia-Induced Unconsciousness.Frontiers in human neuroscience · 2021Article
- Criticality Creates a Functional Platform for Network Transitions Between Internal and External Processing Modes in the Human Brain.Frontiers in systems neuroscience · 2021Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Applying graph theoretical analysis of spontaneous BOLD fluctuations in functional magnetic resonance imaging (fMRI), we investigated whole-brain functional connectivity of 11 healthy volunteers during wakefulness and propofol-induced loss of consciousness (PI-LOC). After extraction of regional fMRI time series from 110 cortical and subcortical regions, we applied a maximum overlap discrete wavelet transformation and investigated changes in the brain's intrinsic spatiotemporal organization. During PI-LOC, we observed a breakdown of subcortico-cortical and corticocortical connectivity. Decrease of connectivity was pronounced in thalamocortical connections, whereas no changes were found for connectivity within primary sensory cortices. Graph theoretical analyses revealed significant changes in the degree distribution and local organization metrics of brain functional networks during PI-LOC: compared with a random network, normalized clustering was significantly increased, as was small-worldness. Furthermore we observed a profound decline in long-range connections and a reduction in whole-brain spatiotemporal integration, supporting a topological reconfiguration during PI-LOC. Our findings shed light on the functional significance of intrinsic brain activity as measured by spontaneous BOLD signal fluctuations and help to understand propofol-induced loss of consciousness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.