ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Distinct neurogenic potential in the retinal margin and the pars plana of mammalian eye.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Cell Sources for Retinal Regeneration: Implication for Data Translation in Biomedicine of the Eye.Cells · 2022Review
- Review
- Potential Endogenous Cell Sources for Retinal Regeneration in Vertebrates and Humans: Progenitor Traits and Specialization.Biomedicines · 2020Review
- Glia-Mediated Regenerative Response Following Acute Excitotoxic Damage in the Postnatal Squamate Retina.Frontiers in cell and developmental biology · 2020Article
- Variations in the proliferative activity of the peripheral retina correlate with postnatal ocular growth in squamate reptiles.The Journal of comparative neurology · 2019Article
- ATN-161 as an Integrin α5β1 Antagonist Depresses Ocular Neovascularization by Promoting New Vascular Endothelial Cell Apoptosis.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Bipotent progenitors as embryonic origin of retinal stem cells.The Journal of cell biology · 2017Article
- Retinal Degeneration and Regeneration-Lessons From Fishes and Amphibians.Current pathobiology reports · 2017Review
- Müller glial cell-dependent regeneration of the neural retina: An overview across vertebrate model systems.Developmental dynamics : an official publication of the American Association of Anatomists · 2016Review
- The human retinal stem niches could overlap a vascular anatomical pattern.Neural regeneration research · 2015Article
- T-box transcription regulator Tbr2 is essential for the formation and maintenance of Opn4/melanopsin-expressing intrinsically photosensitive retinal ganglion cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Advances in repairing the degenerate retina by rod photoreceptor transplantation.Biotechnology advancesReview
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Unlike many other vertebrates, a healthy mammalian retina does not grow throughout life and lacks a ciliary margin zone capable of actively generating new neurons. The isolation of stem-like cells from the ciliary epithelium has led to speculation that the mammalian retina and/or surrounding tissues may retain neurogenic potential capable of responding to retinal damage. Using genetically altered mouse lines with varying degrees of retinal ganglion cell loss, we show that the retinal margin responds to ganglion cell loss by prolonging specific neurogenic activity, as characterized by increased numbers of Atoh7(LacZ)-expressing cells. The extent of neurogenic activity correlated with the degree of ganglion cell deficiency. In the pars plana, but not the retinal margin, cells remain proliferative into adulthood, marking the junction of pars plana and retinal margin as a niche capable of producing proliferative cells in the mammalian retina and a potential cellular source for retinal regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.