ArticleJournal of neurophysiology2012
Hippocampal neuron firing and local field potentials in the in vitro 4-aminopyridine epilepsy model.
Article in Journal of neurophysiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Review
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- Increased neural excitability and glioma synaptic activity drives glioma proliferation in human cortex.Nature neuroscience · 2026Article
- Low glycemic index diet restrains epileptogenesis in a gender-specific fashion.Cellular and molecular life sciences : CMLS · 2023Article
- Digital selective transformation and patterning of highly conductive hydrogel bioelectronics by laser-induced phase separation.Science advances · 2022Article
- Arhgap22 Disruption Leads to RAC1 Hyperactivity Affecting Hippocampal Glutamatergic Synapses and Cognition in Mice.Molecular neurobiology · 2021Article
- Phoenixin-14 reduces the frequency of interictal-like events in mice brain slices.Experimental brain research · 2021Article
- Activation of nicotinic acetylcholine receptors induces potentiation and synchronization within in vitro hippocampal networks.Journal of neurochemistry · 2020Article
- Dynamics of synaptic extracellular field potentials in the nucleus laminaris of the barn owl.Journal of neurophysiology · 2019Article
- GABANeuroscience bulletin · 2018Article
- Treatment with pentylenetetrazole (PTZ) and 4-aminopyridine (4-AP) differently affects survival, locomotor activity, and biochemical markers in Drosophila melanogaster.Molecular and cellular biochemistry · 2018Article
- A Microfluidic Platform for the Characterisation of CNS Active Compounds.Scientific reports · 2017Article
- The antiepileptic and ictogenic effects of optogenetic neurostimulation of PV-expressing interneurons.Journal of neurophysiology · 2016Article
- Network burst activity in hippocampal neuronal cultures: the role of synaptic and intrinsic currents.Journal of neurophysiology · 2016Article
- Genetic upregulation of BK channel activity normalizes multiple synaptic and circuit defects in a mouse model of fragile X syndrome.The Journal of physiology · 2016Article
- Coalescence of deep and superficial epileptic foci into larger discharge units in adult rat neocortex.Neuroscience · 2015Article
- Neural activity propagation in an unfolded hippocampal preparation with a penetrating micro-electrode array.Journal of visualized experiments : JoVE · 2015Article
- Hilar somatostatin interneurons contribute to synchronized GABA activity in an in vitro epilepsy model.PloS one · 2014Article
- Step-by-step instructions for retina recordings with perforated multi electrode arrays.PloS one · 2014Article
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6 authors.
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Abstract
Excessive synchronous neuronal activity is a defining feature of epileptic activity. We previously characterized the properties of distinct glutamatergic and GABAergic transmission-dependent synchronous epileptiform discharges in mouse hippocampal slices using the 4-aminopyridine model of epilepsy. In the present study, we sought to identify the specific hippocampal neuronal populations that initiate and underlie these local field potentials (LFPs). A perforated multielectrode array was used to simultaneously record multiunit action potential firing and LFPs during spontaneous epileptiform activity. LFPs had distinct components based on the initiation site, extent of propagation, and pharmacological sensitivity. Individual units, located in different hippocampal subregions, fired action potentials during these LFPs. A specific neuron subgroup generated sustained action potential firing throughout the various components of the LFPs. The activity of this subgroup preceded the LFPs observed in the presence of antagonists of ionotropic glutamatergic synaptic transmission. In the absence of ionotropic glutamatergic and GABAergic transmission, LFPs disappeared, but units with shorter spike duration and high basal firing rates were still active. These spontaneously active units had an increased level of activity during LFPs and consistently preceded all LFPs recorded before blockade of synaptic transmission. Our findings reveal that neuronal subpopulations with interneuron properties are likely responsible for initiating synchronous activity in an in vitro model of epileptiform discharges.
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