ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2013
Recurrent tuberculosis risk among HIV-infected adults in Tanzania with prior active tuberculosis.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of published literature describing factors associated with tuberculosis recurrence in people living with HIV in Africa.African health sciences · 2015Pooled it
- Vitamin A and D Deficiencies Associated With Incident Tuberculosis in HIV-Infected Patients Initiating Antiretroviral Therapy in Multinational Case-Cohort Study.Journal of acquired immune deficiency syndromes (1999) · 2017Trial
- Loss to follow-up among people living with HIV on tuberculosis preventive treatment at four regional referral hospitals, Uganda, 2019-2021.Journal of clinical tuberculosis and other mycobacterial diseases · 2024Article
- Evaluation of the uptake of tuberculosis preventative therapy for people living with HIV in Namibia: a multiple methods analysis.BMC public health · 2020Article
- Mycobacterium Tuberculosis and Interactions with the Host Immune System: Opportunities for Nanoparticle Based Immunotherapeutics and Vaccines.Pharmaceutical research · 2018Review
- Challenges Across the HIV Care Continuum for Patients With HIV/TB Co-infection in Atlanta, GA [corrected].Open forum infectious diseases · 2018Article
- Integrating tuberculosis screening in Kenyan Prevention of Mother-To-Child Transmission programs.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2017Article
- Predictors and short-term outcomes of recurrent pulmonary tuberculosis, Uganda: a cohort study.South African respiratory journal · 2017Article
- The timing of tuberculosis after isoniazid preventive therapy among gold miners in South Africa: a prospective cohort study.BMC medicine · 2016Article
- Mapping of Mycobacterium tuberculosis Complex Genetic Diversity Profiles in Tanzania and Other African Countries.PloS one · 2016Article
- Effect of isoniazid preventive therapy on tuberculosis or death in persons with HIV: a retrospective cohort study.BMC infectious diseases · 2015Article
- Use of isoniazid preventive therapy for tuberculosis prophylaxis among people living with HIV/AIDS: a review of the literature.Journal of acquired immune deficiency syndromes (1999) · 2015Review
- Risk of tuberculosis among HAART receiving HIV patients attending an ART centre of West Bengal, India: a prospective cohort study.Journal of community health · 2014Article
- Active case finding for tuberculosis among people who inject drugs on methadone treatment in Dar es Salaam, Tanzania.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2014Article
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10 authors.
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Abstract
backgroundActive tuberculosis is common among human immunodeficiency virus (HIV)-infected persons living in tuberculosis-endemic areas, but the hazard of subsequent tuberculosis disease has not been quantified in a single prospective cohort.
methodsAmong HIV-infected, BCG-immunized adults with CD4 counts ≥200 cells/μL who received placebo in the DarDar tuberculosis vaccine trial in Tanzania, we compared the prospective risk of active tuberculosis between subjects who did and who did not report prior active tuberculosis. All subjects with a positive tuberculin skin test without prior active tuberculosis were offered isoniazid preventive treatment. Definite or probable tuberculosis was diagnosed during active follow-up using rigorous published criteria.
resultsWe diagnosed 52 cases of definite and 92 cases of definite/probable tuberculosis among 979 subjects during a median follow-up of 3.2 years. Among the 80 subjects who reported prior active tuberculosis, 11 (13.8%) subsequently developed definite tuberculosis and 17 (21.3%) developed definite/probable tuberculosis, compared with 41 (4.6%) and 75 (8.3%), respectively, of 899 subjects without prior active tuberculosis (definite tuberculosis risk ratio [RR], 3.01; 95% confidence interval [CI], 1.61-5.63, P < .001; definite/probable tuberculosis RR, 2.55; 95% CI, 1.59-4.09, P < .001). In a Cox regression model adjusting for age, CD4 count, and isoniazid receipt, subjects with prior active tuberculosis had substantially greater hazard of subsequent definite tuberculosis (hazard radio [HR], 3.69; 95% CI, 1.79-7.63, P < .001) and definite/probable tuberculosis (HR, 2.78; 95% CI, 1.58-4.87, P < .001).
conclusionsCompared to subjects without prior tuberculosis, the hazard of active tuberculosis is increased 3-fold among HIV-infected adults with prior active tuberculosis. Clinical Trials Registration. NCT0052195.
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