ArticleJournal of clinical microbiology2012
Enteroaggregative Escherichia coli O78:H10, the cause of an outbreak of urinary tract infection.
Article in Journal of clinical microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
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Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Global Extraintestinal Pathogenic Escherichia coli (ExPEC) Lineages.Clinical microbiology reviews · 2019Pooled it
- EnteroaggregativeEcoSal Plus · 2025Review
- Enteroaggregative Escherichia coli (EAEC) isolates obtained from non-diarrheic children carry virulence factor-encoding genes from Extraintestinal Pathogenic E. Coli (ExPEC).Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Genomic Dissection of an EnteroaggregativeInternational journal of molecular sciences · 2024Article
- Detection and characterization of potentially hybrid enteroaggregative Escherichia coli (EAEC) strains isolated from urinary tract infection.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Epidemiology and Risk Factors for Diarrheagenic Escherichia coli Carriage among Children in Northern Ibadan, Nigeria.The American journal of tropical medicine and hygiene · 2023Article
- PCR diagnostics are insufficient for the detection of Diarrhoeagenic Escherichia coli in Ibadan, Nigeria.PLOS global public health · 2023Article
- Virulence Factors and Antimicrobial Resistance of UropathogenicBioMed research international · 2023Article
- Molecular characterization of extraintestinal and diarrheagenicVirulence · 2022Article
- Virulence genes, phylogenetic analysis, and antimicrobial resistance of Escherichia coli isolated from urinary tract infection in hospitalized patients and outpatients.Journal of applied genetics · 2022Article
- Characterization of UropathogenicMicroorganisms · 2022Article
- Molecular Epidemiology and Presence of Hybrid PathogenicMicroorganisms · 2022Article
- The aggregate-forming pili (AFP) mediates the aggregative adherence of a hybrid-pathogenicVirulence · 2021Article
- Article
- Frequency and Diversity of HybridMicroorganisms · 2021Article
- A One Health Perspective for Defining and DecipheringComparative medicine · 2021Review
- EnteroaggregativePeerJ · 2021Article
- Genomic analysis of trimethoprim-resistant extraintestinal pathogenicMicrobial genomics · 2020Article
- Article
- Redefining enteroaggregative Escherichia coli (EAEC): Genomic characterization of epidemiological EAEC strains.PLoS neglected tropical diseases · 2020Article
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10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
In 1991, multiresistant Escherichia coli O78:H10 strains caused an outbreak of urinary tract infections in Copenhagen, Denmark. The phylogenetic origin, clonal background, and virulence characteristics of the outbreak isolates, and their relationship to nonoutbreak O78:H10 strains according to these traits and resistance profiles, are unknown. Accordingly, we extensively characterized 51 archived E. coli O78:H10 isolates (48 human isolates from seven countries, including 19 Copenhagen outbreak isolates, and 1 each of calf, avian, and unknown-source isolates), collected from 1956 through 2000. E. coli O78:H10 was clonally heterogeneous, comprising one dominant clonal group (61% of isolates, including all 19 outbreak isolates) from ST10 (phylogenetic group A) plus several minor clonal groups (phylogenetic groups A and D). All ST10 isolates, versus 25% of non-ST10 isolates, were identified by molecular methods as enteroaggregative E. coli (EAEC) (P < 0.001). Genes present in >90% of outbreak isolates included fimH (type 1 fimbriae; ubiquitous in E. coli); fyuA, traT, and iutA (associated with extraintestinal pathogenic E. coli [ExPEC]); and sat, pic, aatA, aggR, aggA, ORF61, aaiC, aap, and ORF3 (associated with EAEC). An outbreak isolate was lethal in a murine subcutaneous sepsis model and exhibited characteristic EAEC "stacked brick" adherence to cultured epithelial cells. Thus, the 1991 Copenhagen outbreak was caused by a tight, non-animal-associated subset within a broadly disseminated O78:H10 clonal group (ST10; phylogenetic group A), members of which exhibit both ExPEC and EAEC characteristics, whereas O78:H10 isolates overall are phylogenetically diverse. Whether ST10 O78:H10 EAEC strains are both uropathogenic and diarrheagenic warrants further investigation.
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