ArticleParasitology research2013
Protective effect of Azadirachta indica extract against Eimeria papillata-induced coccidiosis.
Article in Parasitology research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 58 citations in OpenAlex.
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- Fighting eimeriosis by using the anti-eimerial and anti-apoptotic properties of rhatany root extract.Frontiers in immunology · 2024Article
- Persea americana extract protects intestinal tissue from Eimeria papillata-induced murine Infection.BMC veterinary research · 2023Article
- Administration of Ethanolic Extract ofMolecules (Basel, Switzerland) · 2023Article
- In Vitro: The Effects of the Anticoccidial Activities ofMolecules (Basel, Switzerland) · 2023Article
- The Anticoccidial Effect of AlcoholicVeterinary sciences · 2023Article
- Biosynthesized selenium nanoparticles to rescue coccidiosis-mediated oxidative stress, apoptosis and inflammation in the jejunum of mice.Frontiers in immunology · 2023Article
- Anthelmintic activity of pomegranate peel extract (Punica granatum) and synthetic anthelmintics against gastrointestinal nematodes in cattle, sheep, goats, and buffalos: in vivo study.Parasitology research · 2021Article
- Ameliorative Effect of Neem Leaf and Pomegranate Peel Extracts in Coccidial Infections in New Zealand and V-Line Rabbits: Performance, Intestinal Health, Oocyst Shedding, Carcass Traits, and Effect on Economic Measures.Animals : an open access journal from MDPI · 2021Article
- Nanoselenium prevents eimeriosis-induced inflammation and regulates mucin gene expression in mice jejunum.International journal of nanomedicine · 2018Article
- Pomegranate (Punica granatum) Juice Shows Antioxidant Activity against Cutaneous Leishmaniasis-Induced Oxidative Stress in Female BALB/c Mice.International journal of environmental research and public health · 2017Article
- Effect of isoflurane + NExperimental and therapeutic medicine · 2017Article
- In vitro evaluation of antifilarial effect ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2017Article
- Anticoccidial activities of Chitosan on Eimeria papillata-infected mice.Parasitology research · 2016Article
- Apoptosis mediated leishmanicidal activity of Azadirachta indica bioactive fractions is accompanied by Th1 immunostimulatory potential and therapeutic cure in vivo.Parasites & vectors · 2015Article
- Antioxidant and anti-inflammatory activities of pomegranate (Punica granatum) on Eimeria papillata-induced infection in mice.BioMed research international · 2015Article
- Protective Effect of Aqueous Crude Extract of Neem (Azadirachta indica) Leaves on Plasmodium berghei-Induced Renal Damage in Mice.Journal of tropical medicine · 2015Article
- Towards identifying novel anti-Eimeria agents: trace elements, vitamins, and plant-based natural products.Parasitology research · 2014Review
- Antiparasitic effect of wild rue (Peganum harmala L.) against experimentally induced coccidiosis in broiler chicks.Parasitology research · 2014Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coccidiosis in poultry is caused by protozoan parasites of the genus Eimeria, which is responsible for worldwide economic losses. The methanolic extract of Azadirachta indica (neem) leaves was used in vivo for its pharmacological, antioxidant, and anticoccidial properties. Four groups of mice were investigated. The first group was inoculated only with sterile saline and served as the control group. The second group was treated by oral gavage with neem extract (500 mg/kg) daily for 4 days. The third and fourth groups were infected with 10(3) sporulated oocysts of Eimeria papillata. The fourth group was also treated once daily with neem extract for 4 days. Paraffin sections from the jejunum as well as jejunal homogenate were prepared for the histopathological and biochemical investigations, respectively. The data showed that mice infected with E. papillata revealed an output of 6.5 × 10(5) ± 29,753 oocysts per gram feces on day 4 postinoculation. This output is significantly decreased to 2.7 × 10(5) ± 37,341 oocysts in neem-treated mice. Infection with E. papillata induced marked histopathological alterations in the jejunum in the form of inflammation, vacuolation of the epithelium, and destruction of some villi. Also, the neem extract greatly diminished body weight loss of infected mice. Moreover, the number of goblet cells stained with Alcian blue within the infected villi was significantly lowered (P ≤ 0.05). In addition, E. papillata enhanced lipid peroxidation and nitric oxide production in both serum and jejunum with concomitant reduction in glutathione. Neem induced marked improvements in all of the studied parameters as well as the histopathological features of the jejunum. Our study revealed that neem as a natural product has protective effects against E. papillata-induced coccidiosis.
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