ArticleThe Journal of general virology2012
Estimating reassortment rates in co-circulating Eurasian swine influenza viruses.
Article in The Journal of general virology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of reported reassortant viral lineages of influenza A.BMC infectious diseases · 2016Pooled it
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- Surveillance for Avian Influenza in Wild Birds in the Lombardy Region (Italy) in the Period 2022-2024.Viruses · 2024Article
- Molecular modeling and phylogenetic analyses highlight the role of amino acid 347 of the N1 subtype neuraminidase in influenza virus host range and interspecies adaptation.Frontiers in microbiology · 2023Article
- Genetic diversification patterns in swine influenza A virus (H1N2) in vaccinated and nonvaccinated animals.Frontiers in cellular and infection microbiology · 2023Article
- Vaccination against swine influenza in pigs causes different drift evolutionary patterns upon swine influenza virus experimental infection and reduces the likelihood of genomic reassortments.Frontiers in cellular and infection microbiology · 2023Article
- Evolution of Swine Influenza Virus H3N2 in Vaccinated and Nonvaccinated Pigs after Previous Natural H1N1 Infection.Viruses · 2022Article
- Genetic Variability among Swine Influenza Viruses in Italy: Data Analysis of the Period 2017-2020.Viruses · 2021Article
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- Current and prospective control strategies of influenza A virus in swine.Porcine health management · 2021Review
- A brief history of bird flu.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
- Computationally optimized broadly reactive vaccine based upon swine H1N1 influenza hemagglutinin sequences protects against both swine and human isolated viruses.Human vaccines & immunotherapeutics · 2019Article
- Origins of the 1918 Pandemic: Revisiting the Swine "Mixing Vessel" Hypothesis.American journal of epidemiology · 2018Article
- Substitution of D701N in the PB2 protein could enhance the viral replication and pathogenicity of Eurasian avian-like H1N1 swine influenza viruses.Emerging microbes & infections · 2018Article
- Adaptive evolution during the establishment of European avian-like H1N1 influenza A virus in swine.Evolutionary applications · 2018Article
- Molecular detection of influenza A(H1N1)pdm09 viruses with M genes from human pandemic strains among Nigerian pigs, 2013-2015: implications and associated risk factors.Epidemiology and infection · 2017Article
- Hydrogen Bond Variations of Influenza A Viruses During Adaptation in Human.Scientific reports · 2017Article
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Authors and funding
11 authors.
Funding
Abstract
Swine have often been considered as a mixing vessel for different influenza strains. In order to assess their role in more detail, we undertook a retrospective sequencing study to detect and characterize the reassortants present in European swine and to estimate the rate of reassortment between H1N1, H1N2 and H3N2 subtypes with Eurasian (avian-like) internal protein-coding segments. We analysed 69 newly obtained whole genome sequences of subtypes H1N1-H3N2 from swine influenza viruses sampled between 1982 and 2008, using Illumina and 454 platforms. Analyses of these genomes, together with previously published genomes, revealed a large monophyletic clade of Eurasian swine-lineage polymerase segments containing H1N1, H1N2 and H3N2 subtypes. We subsequently examined reassortments between the haemagglutinin and neuraminidase segments and estimated the reassortment rates between lineages using a recently developed evolutionary analysis method. High rates of reassortment between H1N2 and H1N1 Eurasian swine lineages were detected in European strains, with an average of one reassortment every 2-3 years. This rapid reassortment results from co-circulating lineages in swine, and in consequence we should expect further reassortments between currently circulating swine strains and the recent swine-origin H1N1v pandemic strain.
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