SynthesisJournal of human hypertension2013
The association between apolipoprotein E gene polymorphisms and essential hypertension: a meta-analysis of 45 studies including 13,940 cases and 16,364 controls.
Synthesis in Journal of human hypertension, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Associations of self-reported obstructive sleep apnea with cognition and dementia risk in cognitively unimpaired middle-aged adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Association of Different Combinations ofInternational journal of general medicine · 2023Article
- Article
- Apolipoprotein E Polymorphism and Frailty: Apolipoprotein ε4 Allele Is Associated with Fatigue but Not Frailty Syndrome in a Community-Dwelling Older Population Cohort.The journal of nutrition, health & aging · 2021Article
- Rare thrombophilic conditions.Annals of translational medicine · 2018Review
- Apolipoprotein E polymorphisms are associated with ischemic stroke susceptibility in a Northwest China Han population.Bioscience reports · 2017Article
- Association of APOE gene polymorphism with lipid profile and coronary artery disease in Afro-Caribbeans.PloS one · 2017Article
- Polymorphisms of apolipoprotein E and aneurysmal subarachnoid haemorrhage: A meta-analysis.Meta gene · 2016Review
- Apolipoprotein E polymorphism and the risk of intracranial aneurysms in a Chinese population.BMC neurology · 2016Article
- Apolipoprotein E, carbon dioxide vasoreactivity, and cognition in older adults: effect of hypertension.Journal of the American Geriatrics Society · 2015Observational
- Signaling pathway genes for blood pressure, folate and cholesterol levels among hypertensives: an epistasis analysis.Journal of human hypertension · 2015Article
- Apolipoprotein E gene E2/E2 genotype is a genetic risk factor for vertebral fractures in humans: a large-scale study.International orthopaedics · 2014Article
- Association of apolipoprotein E polymorphism with maximal oxygen uptake after exercise training: a study of Chinese young adult.Lipids in health and disease · 2014Article
- Apolipoprotein E polymorphism is associated with lower extremity deep venous thrombosis: color-flow Doppler ultrasound evaluation.Lipids in health and disease · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The apolipoprotein E single-nucleotide polymorphisms are among the potential candidate genes that may serve as modulators in susceptibility to essential hypertension. In an effort to clarify earlier inconclusive results, we performed a meta-analysis of population-based case-control genetic association studies. Random-effects methods were applied on summary data in order to combine the results of the individual studies. We identified in total 45 studies, including 13 940 hypertensive cases and 16 364 controls. The contrast of E4 carriers versus non-carriers yielded an overall odds ratio (OR) of 1.16 (95% confidence interval (CI): 1.02, 1.31), whereas the contrast of E4 allele versus the others in a subtotal of 6617 cases and 7330 controls, yielded an OR of 1.39 (95% CI: 1.12, 1.72). There was moderate evidence of publication bias in both contrasts, which was eliminated after excluding studies not in Hardy-Weinberg equilibrium. Subgroup analyses revealed that significant estimates arose from studies on Asian populations, as opposed to the Caucasian ones. Furthermore, no evidence of publication bias was demonstrated in the comparisons within this subgroup. Our results are consistent with recent meta-analyses but show that the association is weaker than that has been previously demonstrated. Further studies are needed in order to fully address questions about the etiological mechanism of the particular association, as well as to study the effect in populations of African descent.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.