Evidence map›Paper›PMID 22971440›Full record

ReviewBiochimie2013

Lipidomic profiling of model organisms and the world's major pathogens.

Emilie Layre, D Branch Moody

Abstract readReview
In one paragraph

Review in Biochimie, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Discovery ofThe Journal of experimental medicine · 2019
    Article
  5. Article
  6. Article
  7. Review
  8. Lipid specific molecular ion emission as a function of the primary ion characteristics in TOF-SIMS.Journal of vacuum science and technology. B, Nanotechnology & microelectronics : materials, processing, measurement, & phenomena : JVST B · 2016
    Article
  9. Article
  10. Article
  11. Monstrous Mycobacterial Lipids.Cell chemical biology · 2016
    Article
  12. Review
  13. Metabolomics: Applications and Promise in Mycobacterial Disease.Annals of the American Thoracic Society · 2015
    Review
  14. Article
  15. Article
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Emilie LayreDivision of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
D Branch Moody

Funding

T cell response to CDI-restricted lipids in tuberculosisR01AI049313 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI MOODY, DAVID BRANCH · 2001 to 2025
$10.6M
Role of Tuberculosinyl Metabolites in M. Tuberculosis VirulenceR01AI116604 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI MOODY, DAVID BRANCH · 2015 to 2019
$2.4M
Remodeling of the M. tuberculosis cell wall during infectionR01AI071155 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI MOODY, DAVID BRANCH · 2006 to 2010
$2.1M
NIAID NIH HHS R01 AI049313NIAID NIH HHS R01 AI071155NIAID NIH HHS R01 AI116604
6 · The paper itself

Abstract

Lipidomics is a subspecialty of metabolomics that focuses on water insoluble metabolites that form membrane barriers. Most lipidomic databases catalog lipids from common model organisms, like humans or Escherichia coli. However, model organisms' lipid profiles show surprisingly little overlap with those of specialized pathogens, creating the need for organism-specific lipidomic databases. Here we review rapid progress in lipidomic platform development with regard to chromatography, detection and bioinformatics. We emphasize new methods of comparative lipidomics, which use aligned datasets to identify lipids changed after introducing a biological variable. These new methods provide an unprecedented ability to broadly and quantitatively describe lipidic change during biological processes and identify changed lipids with low error rates.

Indexed as

Databases, FactualMembrane LipidsMetabolomicsEscherichia coliHumansLipid MetabolismMass SpectrometryMycobacterium tuberculosisMembrane Lipids

Identifiers

PMID22971440
PMCPMC3988492

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.