Observational studyCritical care (London, England)2012
Doppler resistive index to reflect regulation of renal vascular tone during sepsis and acute kidney injury.
Observational study in Critical care (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02558166 (Relation Between the Renal Resistive Index and Markers of the Systemic Circulation, the Microcirculation, Fluid Status and of Renal Function.), which is not on this map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Relation Between the Renal Resistive Index and Markers of the Systemic Circulation, the Microcirculation, Fluid Status and of Renal Function.
Who cites it
47 citing papers in PubMed, 111 citations in OpenAlex.
- Renal resistive index-guided mean arterial pressure titration in sepsis: a prospective single-center, single-blind, parallel-group randomized controlled trial.Nature communications · 2026Trial
- Diagnostic accuracy of doppler-derived renal ultrasound parameters for predicting acute kidney injury after cardiac surgery: a systematic review and meta-analysis.Clinical and experimental nephrology · 2026Article
- ARISE framework: a temporal, multi-organ view of perfusion in sepsis.Internal and emergency medicine · 2026Review
- Exploring the Utility of Renal Resistive Index in Critical Care: Insights into ARDS and Cardiac Failure.Biomedicines · 2025Review
- Observational
- Investigation of 22q11.2 Deletion Syndrome in the first Moroccan Pediatric Patients series.La Tunisie medicale · 2025Article
- Effect of atorvastatin as a renal protective agent in patients with systemic inflammatory response syndrome using the renal arterial resistive index.Acute and critical care · 2025Article
- Performance of urinary C-C motif chemokine ligand 14 and the renal resistive index in predicting persistent AKI.Renal failure · 2024Observational
- Article
- Impact of positive end-expiratory pressure on renal resistive index in mechanical ventilated patients.Journal of clinical monitoring and computing · 2024Article
- Renal arterial resistive index versus novel biomarkers for the early prediction of sepsis-associated acute kidney injury.Internal and emergency medicine · 2024Article
- PASS: A scoring system to evaluate persistent kidney injury in critically ill ICU adult patients.F1000Research · 2023Article
- Performance of the renal resistive index and usual clinical indicators in predicting persistent AKI.Renal failure · 2022Article
- Shock Resuscitation - the Necessity and Priority of Renal Blood Perfusion Assessment.Aging and disease · 2022Article
- Focus on renal blood flow in mechanically ventilated patients with SARS-CoV-2: a prospective pilot study.Journal of clinical monitoring and computing · 2022Observational
- Non-invasive Early Prediction of Septic Acute Kidney Injury by Doppler-Based Renal Resistive Indexes Combined With Echocardiographic Parameters: An Experimental Study.Frontiers in medicine · 2021Article
- Kidney physiology and pathophysiology during heat stress and the modification by exercise, dehydration, heat acclimation and aging.Temperature (Austin, Tex.) · 2021Review
- Feasibility of renal resistive index measurements performed by an intermediate and novice sonographer in a volunteer population.The ultrasound journal · 2020Article
- Intraoperative renal resistive index threshold as an acute kidney injury biomarker.Journal of clinical anesthesia · 2020Article
- Diabetic vasculopathy: macro and microvascular injury.Current pathobiology reports · 2020Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionRenal resistive index (RI), determined by Doppler ultrasonography, directly reveals and quantifies modifications in renal vascular resistance. The aim of this study was to evaluate if mean arterial pressure (MAP) is determinant of renal RI in septic, critically ill patients suffering or not from acute kidney injury (AKI).
methodsThis prospective observational study included 96 patients. AKI was defined according to RIFLE criteria and transient or persistent AKI according to renal recovery within 3 days.
resultsMedian renal RIs were 0.72 (0.68-0.75) in patients without AKI and 0.76 (0.72-0.80) in patients with AKI (P = 0.001). RIs were 0.75 (0.72-0.79) in transient AKI and 0.77 (0.70-0.80) in persistent AKI (P = 0.84). RI did not differ in patients given norepinephrine infusion and was not correlated with norepinephrine dose. RI was correlated with MAP (ρ = -0.47; P = 0.002), PaO2/FiO2 ratio (ρ = -0.33; P = 0.04) and age (ρ = 0.35; P = 0.015) only in patients without AKI.
conclusionsA poor correlation between renal RI and MAP, age, or PaO2/FiO2 ratio was found in septic and critically ill patients without AKI compared to patients with AKI. These findings suggest that determinants of RI are multiple. Renal circulatory response to sepsis estimated by Doppler ultrasonography cannot reliably be predicted simply from changes in systemic hemodynamics. As many factors influence its value, the interest in a single RI measurement at ICU admission to determine optimal MAP remains uncertain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.