ArticleGenetic testing and molecular biomarkers2012
The association between levels of tissue inhibitor of metalloproteinase-1 with acute heart failure and left ventricular dysfunction in patients with ST elevation myocardial infarction treated by primary percutaneous coronary intervention.
Article in Genetic testing and molecular biomarkers, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- The TIMP protein family: diverse roles in pathophysiology.American journal of physiology. Cell physiology · 2024Review
- Myocardial-specific ablation ofThe Journal of biological chemistry · 2019Article
- Systems Genetics Approach to Biomarker Discovery: GPNMB and Heart Failure in Mice and Humans.G3 (Bethesda, Md.) · 2018Article
- Relationship of polymorphisms in the tissue inhibitor of metalloproteinase (TIMP)-1 and -2 genes with chronic heart failure.Scientific reports · 2018Article
- Association ofBiomedical reports · 2017Article
- Nutritional leucine supplementation attenuates cardiac failure in tumour-bearing cachectic animals.Journal of cachexia, sarcopenia and muscle · 2016Article
- EphA2-receptor deficiency exacerbates myocardial infarction and reduces survival in hyperglycemic mice.Cardiovascular diabetology · 2014Article
- Targeting matrix metalloproteinases in heart disease: lessons from endogenous inhibitors.Biochemical pharmacology · 2014Review
- TIMP-1 gene polymorphism: are genetics able to predict outcome of septic patients?Critical care (London, England) · 2013Article
Corrections and comments
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Authors and funding
16 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTissue inhibitors of metalloproteinase (TIMPs) bind to active matrix metalloproteinase (MMPs), and thereby inhibit their proteolytic activity. We investigated the role of polymorphisms in the gene for TIMP-1 and serum levels of TIMP-1 in association with postmyocardial infarction (MI), left ventricular (LV) dysfunction, and symptoms of acute heart failure (AHF) in patients treated with primary percutaneous coronary intervention.
methodsIn total, 556 patients with STEMI were evaluated. Levels of TIMP-1 were measured at admission and 24 h after MI onset. The TIMP-1 exon 5 SNP rs4898 (F124F with T>C) located at X chromosome was assayed.
resultsTIMP-1 levels were higher for men with AHF as well as for men with LV dysfunction (ejection fraction [EF]<40%). According to multivariate analysis, the TIMP-1 level was a factor with an independent negative relationship to EF and AHF in men. An independent relationship between exon 5 TIMP-1 gene polymorphism and EF, AHF or TIMP-1 level was not documented.
conclusionThese results provide evidence that a higher level of circulating TIMP-1 is independently associated with worse EF and AHF.
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